Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Lysophosphatidic acid (LPA) activates six LPA receptors (LPAR 1-6) and regulates various
cellular activities such as cell proliferation, cytoprotection, and wound healing. Many studies …

Although simple in structure, lysophosphatidic acid (LPA) is a potent bioactive lipid that
profoundly influences cellular signaling and function upon binding to G protein-coupled …

Since the clear demonstration of lysophosphatidic acid (LPA)'s pathological roles in cancer
in the mid-1990s, more than 1000 papers relating LPA to various types of cancer were …

Lysophosphatidic acid (LPA) is an active phospholipid signaling molecule that binds to six
specific G protein-coupled receptors (LPA1-6) on the cell surface and exerts a variety of …

Besides serving as a structural membrane component and intermediate of the glycerolipid
metabolism, lysophosphatidic acid (LPA) has a prominent role as a signaling molecule …

Several common chronic diseases, muscular dystrophies (MDs), and aging lead to
progressive fibrous connective tissue (fibrosis) accumulation in skeletal muscle. Cumulative …

Abstract Objective Orexin-A (OX-A) is a neuropeptide produced selectively by neurons of the
lateral hypothalamus. It exerts powerful control over brain function and physiology by …

Lysophosphatidic acid (LPA) is a bioactive lipid that is mainly produced by the secreted
lysophospholipase D, autotaxin (ATX), and signals through at least six G protein-coupled …

Excessive copper can induce many adverse effects although it's an essential trace element
in organisms. The effects of copper on the lipid metabolism have aroused increasing …