Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens
All organisms possess molecular mechanisms that govern DNA repair and associated DNA
damage response (DDR) processes. Owing to their relevance to human disease, most …
damage response (DDR) processes. Owing to their relevance to human disease, most …
Targeting DNA repair pathway in cancer: Mechanisms and clinical application
M Wang, S Chen, D Ao - MedComm, 2021 - Wiley Online Library
Over the last decades, the growing understanding on DNA damage response (DDR)
pathways has broadened the therapeutic landscape in oncology. It is becoming increasingly …
pathways has broadened the therapeutic landscape in oncology. It is becoming increasingly …
Requirement of WDR70 for POLE3-mediated DNA double-strand breaks repair
X Mao, J Wu, Q Zhang, S Zhang, X Chen, X Liu… - Science …, 2023 - science.org
H2BK120ub1 triggers several prominent downstream histone modification pathways and
changes in chromatin structure, therefore involving it into multiple critical cellular processes …
changes in chromatin structure, therefore involving it into multiple critical cellular processes …
DePARylation is critical for S phase progression and cell survival
Poly (ADP-ribose) ylation or PARylation by PAR polymerase 1 (PARP1) and dePARylation
by poly (ADP-ribose) glycohydrolase (PARG) are equally important for the dynamic …
by poly (ADP-ribose) glycohydrolase (PARG) are equally important for the dynamic …
ASF1B promotes oncogenesis in lung adenocarcinoma and other cancer types
W Zhang, Z Gao, M Guan, N Liu, F Meng… - Frontiers in …, 2021 - frontiersin.org
Anti-silencing function 1B histone chaperone (ASF1B) is known to be an important
modulator of oncogenic processes, yet its role in lung adenocarcinoma (LUAD) remains to …
modulator of oncogenic processes, yet its role in lung adenocarcinoma (LUAD) remains to …
[HTML][HTML] CRISPR technology: A versatile tool to model, screen, and reverse drug resistance in cancer
S Shirani-Bidabadi, A Tabatabaee, N Tavazohi… - European Journal of …, 2023 - Elsevier
Background Drug resistance is a serious challenge in cancer treatment that can render
chemotherapy a failure. Understanding the mechanisms behind drug resistance and …
chemotherapy a failure. Understanding the mechanisms behind drug resistance and …
Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma
Ovarian high-grade serous carcinoma (HGSC) is the most common subtype of ovarian
cancer with limited therapeutic options and a poor prognosis. In recent years, poly-ADP …
cancer with limited therapeutic options and a poor prognosis. In recent years, poly-ADP …
Common computational tools for analyzing CRISPR screens
CRISPR–Cas technology offers a versatile toolbox for genome editing, with applications in
various cancer-related fields such as functional genomics, immunotherapy, synthetic …
various cancer-related fields such as functional genomics, immunotherapy, synthetic …
SMG8/SMG9 heterodimer loss modulates SMG1 kinase to drive ATR inhibitor resistance
MJ Llorca-Cardenosa, LI Aronson, DB Krastev… - Cancer Research, 2022 - AACR
Gastric cancer represents the third leading cause of global cancer mortality and an area of
unmet clinical need. Drugs that target the DNA damage response, including ATR inhibitors …
unmet clinical need. Drugs that target the DNA damage response, including ATR inhibitors …
The emerging role of ISWI chromatin remodeling complexes in cancer
Y Li, H Gong, P Wang, Y Zhu, H Peng, Y Cui… - Journal of Experimental …, 2021 - Springer
Disordered chromatin remodeling regulation has emerged as an essential driving factor for
cancers. Imitation switch (ISWI) family are evolutionarily conserved ATP-dependent …
cancers. Imitation switch (ISWI) family are evolutionarily conserved ATP-dependent …