Oxidative stress is a term used to denote the imbalance between the concentrations of
reactive oxygen and nitrogen species and the defense mechanisms of the body. Although it …

Polyphenols (PLPs), phytochemicals found in a wide range of plant-based foods, have
gained extensive attention in view of their antioxidant, anti-inflammatory, immunomodulatory …

Diosgenin (a steroidal saponin of yam) has long been used as a raw material for the
industrial production of steroid drugs, and reported to have a hypocholesterolemic effect by …

Coronary artery disease (CAD) is a multifactorial process that appears to be caused by the
interaction of environmental risk factors with multiple predisposing genes. Genetic research …

DNA damage response (DDR) signaling ensures genomic and proteomic homeostasis to
maintain a healthy genome. Dysregulation either in the form of down‐or upregulation in the …

The contribution of oxidative stress to neurodegeneration is not peculiar of a specific
neurodegenerative disease, oxidative stress has been found implicated in a number of …

OBJECTIVE:: It has been known that there was a relation between the levels of DNA
damage and the severity of the coronary artery disease (CAD). However, little is known …

Background Somatic DNA damage has been suggested to contribute to the pathogenesis of
atherosclerosis. However, little is known about the role of oxidative DNA damage in patients …

Among oxysterols oxidized at C7 (7α-, 7β-hydroxycholesterol, and 7-ketocholesterol) 7β-
hydroxycholesterol and 7-ketocholesterol are potent inducers of cell death and probably …

ketocholesterol, a toxic oxidative product of oxysterol is a causative agent of several
diseases and disabilities concomitant to aging including cardiovascular diseases like …