Overview of growth differentiation factor 15 in metabolic syndrome
Growth and differentiation factor 15 (GDF15) is a member of the transforming growth factor‐β
(TGF‐β) superfamily. GDF15 has been linked with several metabolic syndrome pathologies …
(TGF‐β) superfamily. GDF15 has been linked with several metabolic syndrome pathologies …
Knocking on GDF15's door for the treatment of type 2 diabetes mellitus
D Aguilar-Recarte, E Barroso, X Palomer… - Trends in Endocrinology …, 2022 - cell.com
Although a large number of drugs are available for the treatment of type 2 diabetes mellitus
(T2DM), many patients do not achieve adequate disease control despite adhering to …
(T2DM), many patients do not achieve adequate disease control despite adhering to …
Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor
X Guo, P Asthana, S Gurung, S Zhang… - Nature …, 2022 - nature.com
Insulin sensitivity progressively declines with age. Currently, the mechanism underlying age-
associated insulin resistance remains unknown. Here, we identify membrane-bound matrix …
associated insulin resistance remains unknown. Here, we identify membrane-bound matrix …
Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic. Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2 …
pandemic. Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2 …
Growth differentiation factor 15 regulates oxidative stress-dependent ferroptosis post spinal cord injury by stabilizing the p62-Keap1-Nrf2 signaling pathway
M Xia, Q Zhang, Y Zhang, R Li, T Zhao… - Frontiers in Aging …, 2022 - frontiersin.org
Background Spinal cord injury (SCI) is a severe traumatic disorder of the central nervous
system (CNS) that causes irreversible damage to the nervous tissue. The consequent …
system (CNS) that causes irreversible damage to the nervous tissue. The consequent …
Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis
X Guo, P Asthana, L Zhai, KW Cheng, S Gurung… - Nature …, 2024 - nature.com
Obesity, a global health challenge, is a major risk factor for multiple life-threatening
diseases, including diabetes, fatty liver, and cancer. There is an ongoing need to identify …
diseases, including diabetes, fatty liver, and cancer. There is an ongoing need to identify …
Striking a gut–liver balance for the antidiabetic effects of metformin
Metformin is the most prescribed drug for the treatment of type 2 diabetes mellitus (T2DM),
but its mechanism of action has not yet been completely elucidated. Classically, the liver has …
but its mechanism of action has not yet been completely elucidated. Classically, the liver has …
[HTML][HTML] GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway
Introduction The levels of the cellular energy sensor AMP-activated protein kinase (AMPK)
have been reported to be decreased via unknown mechanisms in the liver of mice deficient …
have been reported to be decreased via unknown mechanisms in the liver of mice deficient …
Emerging roles of growth differentiation factor 15 in immunoregulation and pathogenesis
J Reyes, GS Yap - The Journal of Immunology, 2023 - journals.aai.org
Abstract Growth differentiation factor 15 (GDF-15) is a cytokine that is widely used as a
biomarker for the severity of diverse disease states. It also has been shown to play a …
biomarker for the severity of diverse disease states. It also has been shown to play a …