Conspectus Asymmetric functionalization of alkyl radicals represents a robust yet
underdeveloped method for efficient construction and decoration of carbon skeletons in …

Conspectus The Passerini three-component (P-3CR) and the Ugi four-component (U-4CR)
are two of the most prominent isocyanide-based multicomponent reactions (IMCRs). The P …

Ionizable lipid nanoparticles (LNPs) pivotal to the success of COVID-19 mRNA (messenger
RNA) vaccines hold substantial promise for expanding the landscape of mRNA-based …

A general and efficient method for accessing enantiomerically pure arylpyrroles by utilizing
the catalytic asymmetric Paal-Knorr reaction has been developed for the first time. A wide …

This perspective aims at celebrating the 100th anniversary of the discovery of the Passerini
three component reaction. After being nearly neglected for many years, now this reaction …

Figure 73: The proposed catalyst/substrate interaction shown in Figure 73 corresponds to
the related sulfoxidation catalyzed by chiral phosphoric acid PA 5 (ref 133). Please note that …

Chiral phosphoric acids (CPAs) have been used as efficient organocatalysts since the first
examples were reported 18 years ago by Akiyama and Terada. Although they were …

Reaction of isonitriles with 3‐(arylamino) isobenzofuran‐1 (3H)‐ones in the presence of a
catalytic amount of an octahydro (R)‐binol‐derived chiral phosphoric acid afforded 3‐oxo‐2 …

An effective and economical acid-promoted three-component reaction for the construction of
C–P and C–C bonds for the synthesis of γ-ketophosphine oxides with water as the only …

An efficient enantioselective insertion of α-diazoesters and α-diazoketones into O–H bonds
of carboxylic acids was realized by the use of Rh2 (OAc) 4 and a chiral guanidine. Optically …