The marine environment represents an underexploited resource for the discovery of novel
products, despite its high level of biological and chemical diversity. With increasing …

We propose a conceptual and formal characterisation of biological organisation as a closure
of constraints. We first establish a distinction between two causal regimes at work in …

The rate of biological aging varies cyclically and episodically in response to changing
environmental conditions and the developmentally-controlled biological systems that sense …

Background Hyaluronic acid presents a valuable cosmetic ingredient that occurs naturally.
Its direct links to skin aging has led to its broad application. The aim of this study was to …

One dominant aspect of cities is transport and massive passenger mobilization which
remains a challenge with the increasing demand on the public as cities grow. In addition …

There is consensus among biogerontologists that aging occurs either as the result of a
purposeful genome-based, evolved program or due to spontaneous, randomly occurring …

In this paper, we explore the reduction of functionality in a complex system as a
consequence of cumulative random damage and imperfect reparation, a phenomenon …

We recently introduced Misrepair-accumulation theory as an interpretation on aging
mechanism. For better understanding this theory, we discuss here in more details the new …

Development of a tumor is known to be a result of accumulation of DNA changes in somatic
cells. However, the processes of how DNA changes are produced and how they accumulate …

Age spots are the brown spots that develop in the skin but change in color and shape with
time. To understand the mechanism of development of age spots, characteristics of age …