Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …

Inflammation and neuroinflammation play critical roles in the pathogenesis of
neurodegenerative diseases such as Parkinson's disease (PD). Nanomaterials with reactive …

Mutations in GBA1, the gene encoding the lysosomal enzyme β-glucocerebrosidase
(GCase), which cause Gaucher's disease, are the most frequent genetic risk factor for …

Mutations in SNCA, the gene encoding α-synuclein (αSyn), cause familial Parkinson's
disease (PD) and aberrant αSyn is a key pathological hallmark of idiopathic PD. This α …

The pathogenesis of Parkinson's disease is closely linked to impaired mitochondrial function
and abnormal mitophagy. Biocompatible natural antioxidants effectively protect …

Conspectus The aberrant misfolding and aggregation of peptides and proteins into amyloid
aggregates occurs in over 50 largely incurable protein misfolding diseases. These …

The biological basis of the neurodegenerative movement disorder, Parkinson's disease
(PD), is still unclear despite it being 'discovered'over 200 years ago in Western Medicine …

Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the
pathogenesis of Parkinson's disease and related disorders, synucleinopathies, but also in …

The elucidation of the function of the PINK1 protein kinase and Parkin ubiquitin E3 ligase in
the elimination of damaged mitochondria by autophagy (mitophagy) has provided …

Background Pathological accumulation of aggregated α-synuclein (aSYN) is a common
feature of Parkinson's disease (PD). However, the mechanisms by which intracellular aSYN …