A defining property of retroviruses is their ability to assemble into particles that can leave
producer cells and spread infection to susceptible cells and hosts. Virion morphogenesis …

Over the past several decades, extensive research into the Gag polyprotein, the main
structural protein of HIV-1 and all other retroviruses, has changed the way that we describe …

Immature HIV-1 assembles at and buds from the plasma membrane before proteolytic
cleavage of the viral Gag polyprotein induces structural maturation. Maturation can be …

Proteolytic processing of viral polyproteins is essential for retrovirus infectivity. Retroviral
proteases (PR) become activated during or after assembly of the immature, non-infectious …

Virus assembly and maturation proceed through the programmed operation of molecular
switches, which trigger both local and global structural rearrangements to produce infectious …

During the late stage of the viral life cycle, HIV-1 Gag assembles into a spherical immature
capsid, and undergoes budding, release, and maturation. Here we review events involved in …

The packaging and budding of Gag polyprotein and viral RNA is a critical step in the HIV-1
life cycle. High-resolution structures of the Gag polyprotein have revealed that the capsid …

In recent years, exciting developments in instrument technology and experimental
methodology have advanced the field of magic-angle spinning (MAS) nuclear magnetic …

Retrovirus morphogenesis entails assembly of Gag proteins and the viral genome on the
host plasma membrane, acquisition of the viral membrane and envelope proteins through …

Like other retroviruses, human immunodeficiency virus type 1 (HIV-1) selectively packages
genomic RNA (gRNA) during virus assembly. However, in the absence of the gRNA, cellular …