[HTML][HTML] An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease

E Lee, H Korf, A Vidal-Puig - Journal of hepatology, 2023 - Elsevier
Alongside the liver, white adipose tissue (WAT) is critical in regulating systemic energy
homeostasis. Although each organ has its specialised functions, they must work …

Glucagon-like peptide-1 receptor-based therapeutics for metabolic liver disease

JM Yabut, DJ Drucker - Endocrine Reviews, 2023 - academic.oup.com
Abstract Glucagon-like peptide-1 (GLP-1) controls islet hormone secretion, gut motility, and
body weight, supporting development of GLP-1 receptor agonists (GLP-1RA) for the …

Brown adipose tissue—a translational perspective

AC Carpentier, DP Blondin, F Haman… - Endocrine …, 2023 - academic.oup.com
Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

The metabolic role and therapeutic potential of the microbiome

LE Olofsson, F Bäckhed - Endocrine reviews, 2022 - academic.oup.com
We are host to an assembly of microorganisms that vary in structure and function along the
length of the gut and from the lumen to the mucosa. This ecosystem is collectively known as …

[HTML][HTML] Insulin resistance and adipose tissue interactions as the cornerstone of metabolic (dysfunction)-associated fatty liver disease pathogenesis

SC Pal, N Méndez-Sánchez - World Journal of Gastroenterology, 2023 - ncbi.nlm.nih.gov
The relationship between metabolic derangements and fatty liver development are
undeniable, since more than 75% of patients with type 2 diabetes mellitus present with fatty …

ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP

JF Rahbani, C Scholtes, DM Lagarde, MF Hussain… - Nature …, 2022 - nature.com
Noradrenaline (NA) regulates cold-stimulated adipocyte thermogenesis. Aside from cAMP
signalling downstream of β-adrenergic receptor activation, how NA promotes thermogenic …

Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits

LK Townsend, D Wang, DC Wright, DP Blondin - Nature metabolism, 2023 - nature.com
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits | Nature
Metabolism Skip to main content Thank you for visiting nature.com. You are using a browser …

High-fructose feeding suppresses cold-stimulated brown adipose tissue glucose uptake independently of changes in thermogenesis and the gut microbiome

G Richard, DP Blondin, SA Syed, L Rossi… - Cell Reports …, 2022 - cell.com
Diets rich in added sugars are associated with metabolic diseases, and studies have shown
a link between these pathologies and changes in the microbiome. Given the reported …

Tracers and imaging of fatty acid and energy metabolism of human adipose tissues

AC Carpentier - Physiology, 2024 - journals.physiology.org
White adipose tissue and brown adipose tissue (WAT and BAT) regulate fatty acid
metabolism and control lipid fluxes to other organs. Dysfunction of these key metabolic …

Characteristics of abdominal visceral adipose tissue, metabolic health and the gut microbiome in adults

M U-Din, BA Ahmed, SA Syed, FJ Ong… - The Journal of …, 2024 - academic.oup.com
Context Compared with the relatively benign effects of increased subcutaneous adipose
tissue (SAT), increased visceral adipose tissue (VAT) volume is a causal risk factor for …