Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases

K Khalaf, P Tornese, A Cocco, A Albanese - Translational …, 2022 - Springer
Most neurodegenerative disorders are diseases of protein homeostasis, with misfolded
aggregates accumulating. The neurodegenerative process is mediated by numerous …

Bile salts in digestion and transport of lipids

A Macierzanka, A Torcello-Gómez, C Jungnickel… - Advances in Colloid and …, 2019 - Elsevier
Because of their unusual chemical structure, bile salts (BS) play a fundamental role in
intestinal lipid digestion and transport. BS have a planar arrangement of hydrophobic and …

[HTML][HTML] Exposure to a mixture of legacy, alternative, and replacement per-and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol …

K Roth, Z Yang, M Agarwal, W Liu, Z Peng… - Environment …, 2021 - Elsevier
Background Epidemiological studies have shown Per-and polyfluoroalkyl substances
(PFAS) to be associated with diseases of dysregulated lipid and sterol homeostasis such as …

Human microbiota and breast cancer—is there any relevant link?—a literature review and new horizons toward personalised medicine

D Alpuim Costa, JG Nobre, MV Batista… - Frontiers in …, 2021 - frontiersin.org
Breast cancer (BC) is the most common malignancy and the second cause of cancer-
specific death in women from high-income countries. Recently, gut microbiota dysbiosis …

The biosynthesis, signaling, and neurological functions of bile acids

Y Kiriyama, H Nochi - Biomolecules, 2019 - mdpi.com
Bile acids (BA) are amphipathic steroid acids synthesized from cholesterol in the liver. They
act as detergents to expedite the digestion and absorption of dietary lipids and lipophilic …

Circulating bile acids as a link between the gut microbiota and cardiovascular health: impact of prebiotics, probiotics and polyphenol-rich foods

RAG Pushpass, S Alzoufairi, KG Jackson… - Nutrition Research …, 2022 - cambridge.org
Beneficial effects of probiotic, prebiotic and polyphenol-rich interventions on fasting lipid
profiles have been reported, with changes in the gut microbiota composition believed to play …

Ursodeoxycholic acid and cancer: From chemoprevention to chemotherapy

JF Goossens, C Bailly - Pharmacology & therapeutics, 2019 - Elsevier
Ursodeoxycholic acid (UDCA) is a secondary bile acid issued from the transformation of
(cheno) deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal …

Bile acids as key modulators of the brain-gut-microbiota axis in Alzheimer's disease

A Mulak - Journal of Alzheimer's Disease, 2021 - content.iospress.com
Recently, the concept of the brain-gut-microbiota (BGM) axis disturbances in the
pathogenesis of Alzheimer's disease (AD) has been receiving growing attention. At the …

Gut-derived metabolite indole-3-propionic acid modulates mitochondrial function in cardiomyocytes and alters cardiac function

M Gesper, ABH Nonnast, N Kumowski, R Stoehr… - Frontiers in …, 2021 - frontiersin.org
Background: The gut microbiome has been linked to the onset of cardiometabolic diseases,
in part facilitated through gut microbiota-dependent metabolites such as trimethylamine-N …

Bile acids as regulatory molecules and potential targets in metabolic diseases

A Xie, C Mai, YZ Zhu, XC Liu, Y Xie - Life Sciences, 2021 - Elsevier
Bile acids are important hydroxylated steroids that are synthesized in the liver from
cholesterol for intestinal absorption of lipids and other fatty-nutrient. They also display …