Fibrosis of the diabetic heart: Clinical significance, molecular mechanisms, and therapeutic opportunities

I Tuleta, NG Frangogiannis - Advanced drug delivery reviews, 2021 - Elsevier
In patients with diabetes, myocardial fibrosis may contribute to the pathogenesis of heart
failure and arrhythmogenesis, increasing ventricular stiffness and delaying conduction …

[HTML][HTML] Natural and synthetic antioxidants targeting cardiac oxidative stress and redox signaling in cardiometabolic diseases

M Barteková, A Adameová, A Görbe… - Free Radical Biology …, 2021 - Elsevier
Cardiometabolic diseases (CMDs) are metabolic diseases (eg, obesity, diabetes,
atherosclerosis, rare genetic metabolic diseases, etc.) associated with cardiac pathologies …

Recent advances in the effects of dietary polyphenols on inflammation in vivo: Potential molecular mechanisms, receptor targets, safety issues, and uses of …

D Wang, T Wang, Z Zhang, Z Li, Y Guo, G Zhao… - Current Opinion in Food …, 2022 - Elsevier
High dietary intake of dietary polyphenols is associated with a decreased risk of chronic
diseases, especially in inflammation. However, mechanisms responsible for their anti …

[HTML][HTML] Potential protective function of green tea polyphenol EGCG against high glucose-induced cardiac injury and aging

CC Wan, X Hu, M Li, KRR Rengasamy, Y Cai… - Journal of Functional …, 2023 - Elsevier
Green tea and its active extracts have been widely used in a variety of dietary supplements.
However, to date, the interaction of these bioactive compounds in green tea and their protein …

[HTML][HTML] Glycemic control and the heart: the tale of diabetic cardiomyopathy continues

M Longo, L Scappaticcio, P Cirillo, A Maio… - Biomolecules, 2022 - mdpi.com
Cardiovascular diseases are the leading cause of death in people with diabetes. Diabetic
cardiomyopathy (DC) is an important complication of diabetes and represents a distinct …

[HTML][HTML] The role of serine/threonine protein kinases in cardiovascular disease and potential therapeutic methods

Y Wu, Y Zou, C Song, K Cao, K Cai, S Chen… - Biomedicine & …, 2024 - Elsevier
Protein phosphorylation is an important link in a variety of signaling pathways, and most of
the important life processes in cells involve protein phosphorylation. Based on the amino …

[HTML][HTML] Role of CaMKII in diabetes induced vascular injury and its interaction with anti-diabetes therapy

S Chacar, A Abdi, K Almansoori, J Alshamsi… - Reviews in Endocrine …, 2024 - Springer
Diabetes mellitus is a metabolic disorder denoted by chronic hyperglycemia that drives
maladaptive structural changes and functional damage to the vasculature. Attenuation of this …

[HTML][HTML] Ferroptosis mechanisms and regulations in cardiovascular diseases in the past, present, and future

W Fang, S Xie, W Deng - Cell Biology and Toxicology, 2024 - Springer
Cardiovascular diseases (CVDs) are the main diseases that endanger human health, and
their risk factors contribute to high morbidity and a high rate of hospitalization. Cell death is …

Impact of phytochemicals on PPAR receptors: implications for disease treatments

A Enayati, M Ghojoghnejad, BD Roufogalis… - PPAR …, 2022 - Wiley Online Library
Peroxisome proliferator‐activated receptors (PPARs) are members of the ligand‐dependent
nuclear receptor family. PPARs have attracted wide attention as pharmacologic mediators to …

[HTML][HTML] The current state of preclinical modeling of human diabetic cardiomyopathy using rodents

M Jasińska-Stroschein - Biomedicine & Pharmacotherapy, 2023 - Elsevier
The prevalence of diabetic cardiomyopathy (DCM), a specific cardiovascular complication of
diabetes mellitus, has recently increased. Its pathogenesis is not fully understood, and no …