Sarcopenia is defined as the combined loss of skeletal muscle strength, function, and/or
mass with aging. This degenerative loss of muscle mass is associated with poor quality of …

Discovered in 1993, inositol pyrophosphates are evolutionarily conserved signaling
metabolites whose versatile modes of action are being increasingly appreciated. These …

Circulating phosphate levels are tightly controlled within a narrow range in mammals. By
using a novel small-molecule inhibitor, we show that the enzymatic activity of inositol …

Post-translational modifications (PTMs) of proteins are crucial to guarantee the proper
biological functions in immune responses. Although protein phosphorylation has been …

Inositol pyrophosphates are small, diffusible signaling molecules that possess the most
concentrated three‐dimensional array of phosphate groups in Nature; up to eight …

Inositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds
and fungi to mammals. Distinct classes of kinases generate different forms of energetic …

Obesity and obesity-induced metabolic dysfunctions are significant risk factors for
nonalcoholic fatty liver disease and cardiovascular diseases. Thus, obesity is an economic …

Noncommunicable diseases (NCDs) account for over 70% of deaths world-wide. Previous
work has linked NCDs such as type 2 diabetes (T2D) to disruption of chromatin regulators …

Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7)
are inositol metabolites containing high-energy phosphoanhydride bonds. Biosynthesis of …

Enhancing energy expenditure (EE) is an attractive strategy to combat obesity and diabetes.
Global deletion of Ip6k1 protects mice from diet-induced obesity (DIO) and insulin …