Inflammation and fibrosis in murine models of heart failure

L Bacmeister, M Schwarzl, S Warnke, B Stoffers… - Basic research in …, 2019 - Springer
Heart failure is a consequence of various cardiovascular diseases and associated with poor
prognosis. Despite progress in the treatment of heart failure in the past decades, prevalence …

From inflammation to fibrosis—molecular and cellular mechanisms of myocardial tissue remodelling and perspectives on differential treatment opportunities

N Suthahar, WC Meijers, HHW Silljé… - Current heart failure …, 2017 - Springer
Abstract Purpose of Review In this review, we highlight the most important cellular and
molecular mechanisms that contribute to cardiac inflammation and fibrosis. We also discuss …

Myocarditis in humans and in experimental animal models

P Błyszczuk - Frontiers in cardiovascular medicine, 2019 - frontiersin.org
Myocarditis is defined as an inflammation of the cardiac muscle. In humans, various
infectious and non-infectious triggers induce myocarditis with a broad spectrum of …

Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart

H Bräuninger, B Stoffers, ADE Fitzek… - Cardiovascular …, 2022 - academic.oup.com
Aims Cardiac involvement in COVID-19 is associated with adverse outcome. However, it is
unclear whether cell-specific consequences are associated with cardiac SARS-CoV-2 …

What is the role of the inflammation in the pathogenesis of heart failure?

EC Castillo, E Vázquez-Garza, D Yee-Trejo… - Current Cardiology …, 2020 - Springer
Abstract Purpose of Review In heart failure, whether it is associated with reduced or
preserved ejection fraction, the immune system is activated and contributes to heart …

Myocarditis: etiology, pathogenesis, and their implications in clinical practice

E Brociek, A Tymińska, AS Giordani, ALP Caforio… - Biology, 2023 - mdpi.com
Simple Summary Myocarditis is an inflammatory disease of the myocardium which can lead
to serious short-term and long-term sequalae such as sudden cardiac death or dilated …

Macrophages and galectin 3 play critical roles in CVB3-induced murine acute myocarditis and chronic fibrosis

CJ De Giusti, AE Ure, L Rivadeneyra… - Journal of molecular and …, 2015 - Elsevier
Macrophage influx and galectin 3 production have been suggested as major players driving
acute inflammation and chronic fibrosis in many diseases. However, their involvement in the …

Ruxolitinib ameliorated coxsackievirus B3-induced acute viral myocarditis by suppressing the JAK-STAT pathway

L Chen, M Zhu, G Wang, LL Lu, L Lin, L Lei… - International …, 2023 - Elsevier
Background Accumulating evidences have demonstrated that overwhelming inflammation
occurs in the process of Coxsackievirus B3 (CVB3)-induced acute viral myocarditis (AVM) …

Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis

A Anzai, JE Mindur, L Halle, S Sano, JL Choi… - Journal of Experimental …, 2019 - rupress.org
Acquisition of self-reactive effector CD4+ T cells is a major component of the autoimmune
response that can occur during myocarditis, an inflammatory form of cardiomyopathy …

The roles of cardiac fibroblasts and endothelial cells in myocarditis

Y Xuan, C Chen, Z Wen, DW Wang - Frontiers in cardiovascular …, 2022 - frontiersin.org
In myocarditis caused by various etiologies, activated immune cells and the immune
regulatory factors released by them play important roles. But in this complex …