A unique organelle for studying membrane biochemistry is the mitochondrion whose
functionality depends on a coordinated supply of proteins and lipids. Mitochondria are …

Parkinson's disease (PD) is the second most common neurodegenerative disease, the main
pathological hallmark of which is the accumulation of α-synuclein (α-syn) and the formation …

Human genetics has indicated a causal role for the protein α-synuclein in the pathogenesis
of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all …

Genome-wide association studies (GWAS) have identified several risk variants for late-onset
Alzheimer's disease (LOAD),. These common variants have replicable but small effects on …

The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important
pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells …

Anandamide (N-arachidonoylethanolamine) is known to be an endogenous ligand of
cannabinoid and vanilloid receptors. Its congeners (collectively referred to as N …

Phosphatidic acid (PA) is a critical phospholipid constituent in eukaryotic cell membranes,
which accounts for 1À4% of the total lipid. 1 This lipophilic glycerophospholipid has a …

In mammalian cells, phospholipids and cholesterol are assembled into bilayer membranes
forming the plasma membrane, nuclear envelope, mitochondria, endoplasmic reticulum …

Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain
tumors. The family includes three known proteins: α-synuclein, β-synuclein, and γ-synuclein …

Parkinson's disease is the second most common neurodegenerative disease, after
Alzheimer's disease. Neuropathologically, it is characterized by the degeneration of …