Fibrillin-1 is a major component of the extracellular microfibrils, where it interacts with other
extracellular matrix proteins to provide elasticity to connective tissues, and regulates the …

Abstract The recent pandemic, COVID-19, is caused by a novel coronavirus, SARS-CoV-2,
with elusive origin. SARS-CoV-2 infects mammalian cells via ACE2, a transmembrane …

The mononuclear phagocyte system (MPS) is a family of cells including progenitors,
circulating blood monocytes, resident tissue macrophages, and dendritic cells (DCs) present …

The laboratory rat continues to be the model of choice for many studies of physiology,
behavior, and complex human diseases. Cells of the mononuclear phagocyte system (MPS; …

Abstract Objective Pancreatic islets of Langerhans secrete hormones to regulate systemic
glucose levels. Emerging evidence suggests that islet cells are functionally heterogeneous …

Lymphocytes can heavily influence intestinal health, but resolving intestinal lymphocyte
function is challenging as the intestine contains a vastly heterogeneous mixture of cells. Pigs …

Background There is a need for functional genome-wide annotation of the protein-coding
genes to get a deeper understanding of mammalian biology. Here, a new annotation …

Background A comprehensive analysis of gene expression profiling across tissues can
provide necessary information for an in-depth understanding of their biological functions. We …

Mammalian macrophages differ in their basal gene expression profiles and response to the
toll-like receptor 4 (TLR4) agonist, lipopolysaccharide (LPS). In human macrophages, LPS …

There is very little information about how the genome is regulated in domestic pigs (Sus
scrofa). This lack of knowledge hinders efforts to define and predict the effects of genetic …