Neuroprotective activity of sitagliptin via reduction of neuroinflammation beyond the incretin effect: Focus on Alzheimer's disease
M Wiciński, E Wódkiewicz, M Słupski… - BioMed Research …, 2018 - Wiley Online Library
Sitagliptin is a member of a class of drugs that inhibit dipeptidyl peptidase (DPP‐4). It
increases the levels of the active form of incretins such as GLP‐1 (glucagon‐like peptide‐1) …
increases the levels of the active form of incretins such as GLP‐1 (glucagon‐like peptide‐1) …
Combination of vitamin D and dipeptidyl peptidase-4 inhibitors (VIDPP-4i) as an immunomodulation therapy for autoimmune diabetes
Abstract Type 1 diabetes (T1D) and latent autoimmune diabetes in adults (LADA) represent
the most common types of autoimmune diabetes and are characterized by different age of …
the most common types of autoimmune diabetes and are characterized by different age of …
Inflammation: A bridge between diabetes and COVID-19, and possible management with sitagliptin
Patients with SARS-CoV-2 infections experience lymphopenia and inflammatory cytokine
storms in the severe stage of the disease, leading to multi-organ damage. The exact pattern …
storms in the severe stage of the disease, leading to multi-organ damage. The exact pattern …
The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment
I Piątkowska-Chmiel, M Gawrońska-Grzywacz… - Scientific Reports, 2022 - nature.com
Diabetes is a chronic disease leading to memory difficulties and deterioration of learning
abilities. The previous studies showed that modulation of inflammatory pathways in the …
abilities. The previous studies showed that modulation of inflammatory pathways in the …
Role of cytotoxicity experiments in pharmaceutical development
Through the twentieth century, the road from synthetizing a new drug molecule to become
an actual product got longer than ever before. Cytotoxicity assays are a quick way to assess …
an actual product got longer than ever before. Cytotoxicity assays are a quick way to assess …
Anti-fibrotic activity of sitagliptin against concanavalin A-induced hepatic fibrosis. Role of Nrf2 activation/NF-κB inhibition
Sitagliptin is known for its anti-diabetic activity though it has other pleiotropic
pharmacological actions. Its effect against concanavalin A (Con A)-induced hepatic fibrosis …
pharmacological actions. Its effect against concanavalin A (Con A)-induced hepatic fibrosis …
Self-Nanoemulsifying Drug Delivery Systems Containing Plantago lanceolata—An Assessment of Their Antioxidant and Antiinflammatory Effects
The most important components of Plantago lanceolata L. leaves are catalpol, aucubin, and
acteoside (= verbascoside). These bioactive compounds possess different pharmacological …
acteoside (= verbascoside). These bioactive compounds possess different pharmacological …
[HTML][HTML] Anti-inflammatory and antinociceptive effects of sitagliptin in animal models and possible mechanisms involved in the antinociceptive activity
V Hajhashemi, H Sadeghi, FK Madab - The Korean Journal of Pain, 2024 - ncbi.nlm.nih.gov
Background Sitagliptin is an antidiabetic drug that inhibits dipeptidyl peptidase-4 enzyme.
This study aimed to investigate the antinociceptive and anti-inflammatory effects of sitagliptin …
This study aimed to investigate the antinociceptive and anti-inflammatory effects of sitagliptin …
Glial cell type-specific changes in spinal dipeptidyl peptidase 4 expression and effects of its inhibitors in inflammatory and neuropatic pain
K Király, M Kozsurek, E Lukácsi, B Barta, A Alpár… - Scientific Reports, 2018 - nature.com
Altered pain sensations such as hyperalgesia and allodynia are characteristic features of
various pain states, and remain difficult to treat. We have shown previously that spinal …
various pain states, and remain difficult to treat. We have shown previously that spinal …
Sitagliptin attenuates intestinal ischemia/reperfusion injury via cAMP/PKA, PI3K/Akt pathway in a glucagon-like peptide 1 receptor-dependent manner
Aims This study investigated the effect of sitagliptin prophylactic treatment on intestinal I/R
rat model and explored the possible underlying mechanism. Main methods Forty-five male …
rat model and explored the possible underlying mechanism. Main methods Forty-five male …