The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer,
but new platinum agents have been very slow to enter the clinic. Recently, however, there …

The actions of estrogens and related estrogenic molecules are complex and multifaceted in
both sexes. A wide array of natural, synthetic, and therapeutic molecules target pathways …

Estrogen receptors alpha (ERα) and beta (ERβ) are nuclear transcription factors that are
involved in the regulation of many complex physiological processes in humans. Modulation …

Neuroinflammation is a physiological protective response in the context of infection and
injury. However, neuroinflammation, especially if chronic, may also drive …

Inflammatory activation of microglia is a hallmark of several disorders of the central nervous
system. In addition to protecting the brain against inflammatory insults, microglia are …

Platinum-based anticancer drugs occupy a crucial role in the treatment of various malignant
tumours. However, the efficacy and applicability of platinum drugs are heavily restricted by …

Isoflavones are phytoestrogens with potent estrogenic activity; genistein, daidzein and
glycitein are the most active isoflavones found in soy beans. Phytoestrogens have similarity …

Estrogen receptors (ER) include ER alpha, ER beta and new membrane receptor G protein-
coupled receptor 30 (GPR30). Estrogen receptors are key receptors to maintain ovarian …

Aging is associated with a loss of sex hormone in both men (andropause) and women
(menopause). In men, reductions in testosterone can trigger declines in muscle mass, bone …

We have developed an experimental strategy to monitor protein interactions in a cell with a
high degree of selectivity and sensitivity. A transcription factor is tethered to a membrane …