Context.—Chordomas are uncommon malignant neoplasms with notochordal differentiation
encountered by neuropathologists, bone/soft tissue pathologists, and general surgical …

The last decade has seen the majority of primary bone tumor subtypes become defined by
molecular genetic alteration. Examples include giant cell tumour of bone (H3F3A p. G34W) …

Many diseases, including cancer, stem from aberrant activation or overexpression of
oncoproteins that are associated with multiple signaling pathways. Although proteins with …

Measurements of very low levels of biomolecules, including proteins and nucleic acids,
remain a critical challenge in many clinical diagnostic applications due to insufficient …

Chordoma is a primary bone cancer with no approved therapy. The identification of
therapeutic targets in this disease has been challenging due to the infrequent occurrence of …

Chordoma is a malignant, often incurable bone tumour showing notochordal differentiation.
Here, we defined the somatic driver landscape of 104 cases of sporadic chordoma. We …

Brachyury is a transcription factor of the T-box family typically expressed in notochord and
chordoma. Some studies report brachyury as highly specific for chordoma, whereas others …

Objectives: Chordoma is a rare bone malignancy that affects the spine and skull base.
Treatment dilemma leads to a high rate of local relapse and distant metastases. Molecular …

The notochord is an embryonic midline structure common to all members of the phylum
Chordata, providing both mechanical and signaling cues to the developing embryo. In …

Retroperitoneal tumors are extremely rare. More than 70% of primary retroperitoneal soft
tissue tumors are malignant. The most common sarcomas in the retroperitoneum include …