Chordoma: a review and differential diagnosis
V Ulici, J Hart - Archives of Pathology & Laboratory …, 2022 - meridian.allenpress.com
Context.—Chordomas are uncommon malignant neoplasms with notochordal differentiation
encountered by neuropathologists, bone/soft tissue pathologists, and general surgical …
encountered by neuropathologists, bone/soft tissue pathologists, and general surgical …
An update of molecular pathology of bone tumors. Lessons learned from investigating samples by next generation sequencing
D Baumhoer, F Amary… - Genes, Chromosomes …, 2019 - Wiley Online Library
The last decade has seen the majority of primary bone tumor subtypes become defined by
molecular genetic alteration. Examples include giant cell tumour of bone (H3F3A p. G34W) …
molecular genetic alteration. Examples include giant cell tumour of bone (H3F3A p. G34W) …
[HTML][HTML] Targeted degradation of transcription factors by TRAFTACs: transcription factor targeting chimeras
KTG Samarasinghe, S Jaime-Figueroa, M Burgess… - Cell chemical …, 2021 - cell.com
Many diseases, including cancer, stem from aberrant activation or overexpression of
oncoproteins that are associated with multiple signaling pathways. Although proteins with …
oncoproteins that are associated with multiple signaling pathways. Although proteins with …
Ultrasensitive detection of attomolar protein concentrations by dropcast single molecule assays
Measurements of very low levels of biomolecules, including proteins and nucleic acids,
remain a critical challenge in many clinical diagnostic applications due to insufficient …
remain a critical challenge in many clinical diagnostic applications due to insufficient …
Small-molecule targeting of brachyury transcription factor addiction in chordoma
Chordoma is a primary bone cancer with no approved therapy. The identification of
therapeutic targets in this disease has been challenging due to the infrequent occurrence of …
therapeutic targets in this disease has been challenging due to the infrequent occurrence of …
[HTML][HTML] The driver landscape of sporadic chordoma
Chordoma is a malignant, often incurable bone tumour showing notochordal differentiation.
Here, we defined the somatic driver landscape of 104 cases of sporadic chordoma. We …
Here, we defined the somatic driver landscape of 104 cases of sporadic chordoma. We …
Nuclear brachyury expression is consistent in chordoma, common in germ cell tumors and small cell carcinomas, and rare in other carcinomas and sarcomas: an …
M Miettinen, Z Wang, J Lasota, C Heery… - The American journal …, 2015 - journals.lww.com
Brachyury is a transcription factor of the T-box family typically expressed in notochord and
chordoma. Some studies report brachyury as highly specific for chordoma, whereas others …
chordoma. Some studies report brachyury as highly specific for chordoma, whereas others …
[HTML][HTML] Molecular targeted therapy in the treatment of chordoma: a systematic review
T Meng, J Jin, C Jiang, R Huang, H Yin, D Song… - Frontiers in …, 2019 - frontiersin.org
Objectives: Chordoma is a rare bone malignancy that affects the spine and skull base.
Treatment dilemma leads to a high rate of local relapse and distant metastases. Molecular …
Treatment dilemma leads to a high rate of local relapse and distant metastases. Molecular …
The notochord: structure and functions
The notochord is an embryonic midline structure common to all members of the phylum
Chordata, providing both mechanical and signaling cues to the developing embryo. In …
Chordata, providing both mechanical and signaling cues to the developing embryo. In …
[HTML][HTML] Updates in pathology for retroperitoneal soft tissue sarcoma
T Mack, B Purgina - Current Oncology, 2022 - mdpi.com
Retroperitoneal tumors are extremely rare. More than 70% of primary retroperitoneal soft
tissue tumors are malignant. The most common sarcomas in the retroperitoneum include …
tissue tumors are malignant. The most common sarcomas in the retroperitoneum include …