The pathobiology of human fungal infections

GD Brown, ER Ballou, S Bates, EM Bignell… - Nature Reviews …, 2024 - nature.com
Human fungal infections are a historically neglected area of disease research, yet they
cause more than 1.5 million deaths every year. Our understanding of the pathophysiology of …

[HTML][HTML] Microglial activation and polarization in type 2 diabetes-related cognitive impairment: A focused review of pathogenesis

Y Tian, G Jing, M Ma, R Yin, M Zhang - Neuroscience & Biobehavioral …, 2024 - Elsevier
Microglia, as immune cells in the central nervous system, are closely related to cognitive
impairment associated with type 2 diabetes (T2D). Preliminary explorations have …

Microbiota–gut–brain axis: interplay between microbiota, barrier function and lymphatic system

M Zhuang, X Zhang, J Cai - Gut Microbes, 2024 - Taylor & Francis
The human gastrointestinal tract, boasting the most diverse microbial community, harbors
approximately 100 trillion microorganisms comprising viruses, bacteria, fungi, and archaea …

Recent trends in treatment strategies for Alzheimer's disease and the challenges: A topical advancement

N Liu, X Liang, Y Chen, L Xie - Ageing Research Reviews, 2024 - Elsevier
Alzheimer's Disease (AD) is an irreversible and progressive neurological disease that has
affected at least 50 million people around the globe. Considering the severity of the disease …

Gut microbe–host interactions in post-COVID syndrome: a debilitating or restorative partnership?

TPM Scheithauer, RC Montijn, A Mieremet - Gut Microbes, 2024 - Taylor & Francis
Post-COVID syndrome (PCS) patients have reported a wide range of symptoms, including
fatigue, shortness of breath, and diarrhea. Particularly, the presence of gastrointestinal …

Endothelial DR6 in blood-brain barrier malfunction in Alzheimer's disease

X Huang, J Qi, Y Su, Y Zhou, Q Wang, T Huang… - Cell Death & …, 2024 - nature.com
The impairment of the blood-brain barrier (BBB) has been increasingly recognised as a
critical element in the early pathogenesis of Alzheimer's disease (AD), prompting a focus on …

[HTML][HTML] Ablation of the integrin CD11b mac-1 limits deleterious responses to traumatic spinal cord injury and improves functional recovery in mice

Y Li, Z Lei, RM Ritzel, J He, S Liu, L Zhang, J Wu - Cells, 2024 - mdpi.com
Spinal cord injury (SCI) triggers microglial/monocytes activation with distinct pro-
inflammatory or inflammation-resolving phenotypes, which potentiate tissue damage or …

Sensory Dysfunction, Microbial Infections, and Host Responses in Alzheimer's Disease

P Bathini, E Brai, BJ Balin, L Bimler… - The Journal of …, 2024 - academic.oup.com
Sensory functions of organs of the head and neck allow humans to interact with the
environment and establish social bonds. With aging, smell, taste, vision, and hearing …

Studies on the antifungal effects of Hinokitiol on Candida albicans: inhibition of germ tube formation and synergistic pharmacological effects of miconazole

N Takeuchi, K Fukui, K Nakamura, A Tanaka - Odontology, 2024 - Springer
One of the goals of oral healthcare management is to manage dry mouth. Thus, moisturizers
containing antimicrobial ingredients, such as hinokitiol (HT), are applied to the oral mucosa …

The Candida Covid Connection: Preexisting Candida Overgrowth and Gut Dysbiosis Drives Long Covid

P Chambers - 2023 - preprints.org
Long Covid has become a blight, its economic consequences overwhelming. But Long
Covid (LC) may represent persistent Covid-19 in those with preexisting Candida overgrowth …