Neurodegenerative disorders are chronic and life-threatening conditions negatively affecting
the quality of patients' lives. They often have a genetic background, but oxidative stress and …

Individuals living with HIV who are optimally treated with combination antiretroviral therapy
(cART) can now lead an extended life. In spite of this remarkable survival benefit from viral …

Over the last two decades, evidence for the involvement of quinolinic acid (QUIN) in
neuroinflammatory diseases has been exponentially increasing. Within the brain, QUIN is …

Background Immune dysfunction, including monocytosis and increased blood levels of
interleukin-1, interleukin-6 and tumour necrosis factor α has been observed during acute …

Quinolinic acid (QUIN), a neuroactive metabolite of the kynurenine pathway, is normally
presented in nanomolar concentrations in human brain and cerebrospinal fluid (CSF) and is …

Tryptophan is an essential amino acid that can be metabolised through different pathways, a
major route being the kynurenine pathway. The first enzyme of the pathway, indoleamine-2 …

The kynurenine pathway is important in cellular energy generation and limiting cellular
ageing as it degrades about 90% of dietary tryptophan into the essential co-factor NAD+ …

The metabolism of the amino acid l-tryptophan is a highly regulated physiological process
leading to the generation of several neuroactive compounds within the central nervous …

There has been considerable scientific effort dedicated to understanding the biologic
consequence and therapeutic implications of aberrant tryptophan metabolism in brain …

Obesity and related metabolic conditions are of epidemic proportions in most of the world,
affecting both adults and children. The accumulation of lipids in the body in the form of white …