Hypertension in chronic kidney disease: What lies behind the scene

OZ Ameer - Frontiers in pharmacology, 2022 - frontiersin.org
Hypertension is a frequent condition encountered during kidney disease development and a
leading cause in its progression. Hallmark factors contributing to hypertension constitute a …

Cardiovascular autonomic dysfunction in chronic kidney disease: a comprehensive review

IM Salman - Current hypertension reports, 2015 - Springer
Cardiovascular autonomic dysfunction is a major complication of chronic kidney disease
(CKD), likely contributing to the high incidence of cardiovascular mortality in this patient …

Major autonomic neuroregulatory pathways underlying short-and long-term control of cardiovascular function

IM Salman - Current hypertension reports, 2016 - Springer
Short-term and long-term blood pressure (BP) regulation and its maintenance at levels
adequate to perfuse tissue organs involve an integrated action of multiple neural …

Low intensity stimulation of aortic baroreceptor afferent fibers as a potential therapeutic alternative for hypertension treatment

IM Salman, OZ Ameer, S McMurray, SF Hassan… - Scientific reports, 2022 - nature.com
Carotid baroreceptor stimulation has been clinically explored for antihypertensive benefits,
but neuromodulation of aortic baroreceptor afferents remains unexplored for potential …

Renal denervation does not affect hypertension or the renin-angiotensin system in a rodent model of juvenile-onset polycystic kidney disease: clinical implications

S Li, CM Hildreth, AA Rahman, SA Barton, BF Wyse… - Scientific Reports, 2021 - nature.com
We examined the effect of total and afferent renal denervation (RDN) on hypertension and
the renin-angiotensin system (RAS) in a rodent model of juvenile-onset polycystic kidney …

[HTML][HTML] Baroreflex dysfunction in chronic kidney disease

M Kaur, DS Chandran, AK Jaryal… - World journal of …, 2016 - ncbi.nlm.nih.gov
Chronic kidney disease (CKD) patients have high cardiovascular mortality and morbidity.
The presence of traditional and CKD related risk factors results in exaggerated vascular …

Key challenges in exploring the rat as a preclinical neurostimulation model for aortic baroreflex modulation in hypertension

IM Salman - Hypertension Research, 2024 - nature.com
Electrode-based electrophysiological interfaces with peripheral nerves have come a long
way since the 1960s, with several neurostimulation applications witnessing widespread …

Uraemia: an unrecognized driver of central neurohumoral dysfunction in chronic kidney disease?

CF Underwood, CM Hildreth, BF Wyse… - Acta …, 2017 - Wiley Online Library
Chronic kidney disease (CKD) carries a large cardiovascular burden in part due to
hypertension and neurohumoral dysfunction–manifesting as sympathetic overactivity …

Differential frequency-dependent reflex summation of the aortic baroreceptor afferent input

IM Salman - Pflügers Archiv-European Journal of Physiology, 2023 - Springer
Reflex summation in the expression of left and right aortic baroreflex control of
hemodynamic functions was investigated. In anesthetized Sprague–Dawley rats, mean …

Direct conscious telemetry recordings demonstrate increased renal sympathetic nerve activity in rats with chronic kidney disease

IM Salman, D Sarma Kandukuri, JL Harrison… - Frontiers in …, 2015 - frontiersin.org
Chronic kidney disease (CKD) is associated with sympathetic hyperactivity and impaired
blood pressure control reflex responses, yet direct evidence demonstrating these features of …