The same mutation can have different effects in different individuals. One important reason
for this is that the outcome of a mutation can depend on the genetic context in which it …

The face of evolutionary biology is changing: from reconstructing and analysing the past to
predicting future evolutionary processes. Recent developments include prediction of …

Motivation: Recent developments of statistical techniques to infer direct evolutionary
couplings between residue pairs have rendered covariation-based contact prediction a …

To what extent is the convergent evolution of protein function attributable to convergent or
parallel changes at the amino acid level? The mutations that contribute to adaptive protein …

Epistasis for fitness means that the selective effect of a mutation is conditional on the genetic
background in which it appears. Although epistasis is widely observed in nature, our …

Motivation: Compensating alterations during the evolution of protein families give rise to
coevolving positions that contain important structural and functional information. However, a …

Proteins are finicky molecules; they are barely stable and are prone to aggregate, but they
must function in a crowded environment that is full of degradative enzymes bent on their …

'Disease-causing'mutations do not cause disease in all individuals. One possible important
reason for this is that the outcome of a mutation can depend upon other genetic variants in a …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

Why do proteins evolve at different rates? Advances in systems biology and genomics have
facilitated a move from studying individual proteins to characterizing global cellular factors …