For decades, multiple attempts to fully understand knee osteoarthritis pathophysiology and
natural history have been attempted. Despite the extensive amount of research regarding …

Intra-articular drug delivery has a number of advantages over systemic administration;
however, for the past 20 years, intra-articular treatment options for the management of knee …

This guideline provides recommendations for clinicians providing pain care, including those
prescribing opioids, for outpatients aged≥ 18 years. It updates the CDC Guideline for …

Importance Primary care clinicians find managing chronic pain challenging. Evidence of
long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious …

Pain is the major symptom of osteoarthritis (OA) and is an important factor in strategies to
manage this disease. However, the current standard of care does not provide satisfactory …

Objective To develop concise, up-to-date, patient-focused, evidence-based, expert
consensus guidelines for the management of knee osteoarthritis (OA), intended to inform …

Osteoarthritis (OA) of the hip and knee is among the most common joint disorders. Intra-
articular corticosteroid (IACS) injections are frequently performed to treat OA and other joint …

Background & aims Musculoskeletal pain, the most common cause of disability globally, is
most frequently managed in primary care. People with musculoskeletal pain in different body …

Background: The relative efficacy of available treatments of knee osteoarthritis (OA) must be
determined for rational treatment algorithms to be formulated. Purpose: To examine the …

Mesenchymal stem cells (MSCs) are known to have a potential for articular cartilage
regeneration. However, most studies focused on focal cartilage defect through surgical …