Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

Sumoylation is an essential post‐translational modification intimately involved in a diverse
range of eukaryotic cellular mechanisms. Small ubiquitin‐like modifier (SUMO) protein …

Background Radiotherapy (RT) is a highly effective multimodal nonsurgical treatment that is
essential for patients with advanced colorectal cancer (CRC). Nevertheless, cell …

The regulation of protein fate by modification with the small ubiquitin-related modifier
(SUMO) plays an essential and crucial role in most cellular pathways. Sumoylation is highly …

SUMOylation, as a post-translational modification, plays essential roles in various biological
functions including cell growth, migration, cellular responses to stress and tumorigenesis …

Cancer stem cells (CSCs) represent a major source of treatment resistance and tumor
progression. However, regulation of CSCs stemness is not entirely understood. Here, we …

Environmental benzo (a) pyrene (BaP) and its ultimate metabolite BPDE (benzo (a) pyrene-
7, 8-dihydrodiol-9, 10-epoxide) are universal and inevitable persistent organic pollutants …

Background Colon cancer (CC) cells can exhibit stemness and expansion capabilities,
which contribute to resistance to conventional chemotherapies. Aberrant expression of …

Post-translational modifications of cellular substrates with ubiquitin and ubiquitin-like
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …

Objective We investigated the effect and mechanism of hypoxic microenvironment and
hypoxia-inducible factors (HIFs) on hepatocellular carcinoma (HCC) cancer stemness …