Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …

Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Hepatocytes are epithelial cells with highly specialized polarity. The disorder and loss of
hepatocyte polarity leads to a weakness of cell adhesion and connection, the induction of …

Serine palmitoyl transferase (SPT), the rate-limiting enzyme in the de novo synthesis of
sphingolipids (SL), is needed for embryonic development, physiological homeostasis, and …

Hyperlipidemia, characterized by high serum lipids, is a risk factor for cardiovascular
disease. Recent studies have identified an important role for celastrol, a proteasome …

Sphingolipids and cholesterol are two lipid partners on cellular membranes where they form
specific microdomains, named lipid rafts, which mediate specific cell functions …

Serine palmitoyltransferase (SPT) is the rate-limiting enzyme for sphingolipid biosynthesis.
SPT has two major subunits, SPTLC1 and SPTLC2. We previously found that liver Sptlc2 …

Glucosylceramide (GluCer) was accumulated in sphingomyelin synthase 1 (SMS1) but not
SMS2 deficient mouse tissues. In current study, we studied GluCer accumulation-mediated …

Simple Summary The sphingolipid metabolic pathway, an important signaling pathway,
plays a crucial role in various physiological processes including immune regulation, cell …

Background & Aims During liver regeneration after partial hepatectomy, the function and
metabolic pathways governing transient lipid droplet accumulation in hepatocytes remain …