Intervertebral disc (IVD) degeneration is a common finding on spine imaging that increases
in prevalence with age. IVD degeneration is a frequent cause of low back pain, which is a …

Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …

Exosome therapy is a promising therapeutic approach for intervertebral disc degeneration
(IVDD) and achieves its therapeutic effects by regulating metabolic disorders, the …

Intervertebral disc (IVD) degeneration is a major cause of low back pain, a prevalent and
chronic condition that has a striking effect on quality of life. Currently, no approved …

Although injectable hydrogel microsphere has demonstrated tremendous promise in clinical
applications, local overactive inflammation in degenerative diseases could jeopardize …

A comprehensive understanding of the cellular heterogeneity and molecular mechanisms
underlying the development, homeostasis, and disease of human intervertebral disks (IVDs) …

Intervertebral disk (IVD) degeneration is a natural progression of the aging process.
Degenerative disk disease (DDD) is a pathologic condition associated with IVD that has …

Excessive oxidative stress and inflammation are the key early events in the development of
intervertebral disc degeneration (IVDD). The NACHT, LRR, and PYD domain-containing …

Musculoskeletal disorders represent a major cause of disability and morbidity globally and
result in enormous costs for health and social care systems. Development of cell-based …

Intervertebral disc degeneration (IDD) is the primary pathological mechanism that underlies
low back pain. Overloading-induced cell death, especially endogenous stem cell death, is …