Neural stem cells (NSCs) provide promising approaches for investigating embryonic
neurogenesis, modeling of the pathogenesis of diseases of the central nervous system, and …

The first mammalian Wnt to be discovered, Wnt-1, was found to be essential for the
development of a large part of the mouse brain over 25 years ago. We have since learned …

Understanding the mechanisms regulating pluripotency in embryonic and induced
pluripotent stem cells is required to ensure their safe use in clinical applications. Glycogen …

Many intergenic long noncoding RNA (lncRNA) loci regulate the expression of adjacent
protein coding genes. Less clear is whether intergenic lncRNAs commonly regulate …

Wnts are a highly conserved family of lipid-modified glycoproteins that work as morphogens
to activate several signaling pathways, leading to remodeling of the cytoskeleton and the …

Wnts are a family of secreted proteins that regulate multiple steps of neural development
and stem cell differentiation. Two of them, Wnt1 and Wnt5a, activate distinct branches of Wnt …

The severe disorders associated with a loss or dysfunction of midbrain dopamine neurons
(DNs) have intensified research aimed at deciphering developmental programs controlling …

Perturbed neuronal migration and circuit development have been implicated in the
pathogenesis of neurodevelopmental diseases; however, the direct steps linking these …

The mesodiencephalic dopaminergic (mdDA) group of neurons comprises molecularly
distinct subgroups, of which the substantia nigra (SN) and ventral tegmental area (VTA) are …

The mitochondrion is emerging as a key organelle in stem cell biology, acting as a regulator
of stem cell pluripotency and differentiation. In this study we sought to understand the effect …