Tissue regeneration following injury from disease or medical treatment still represents a
challenge in regeneration medicine. Prostaglandin E2 (PGE2), which involves diverse …

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used
therapeutic class in clinical medicine. These are sub-divided based on their selectivity for …

Accumulating evidence indicatesthat programmed necrosis plays a critical role in cell death
during ischemia–reperfusion. Necrostatin-1 (Nec-1), a small molecule capable of inhibiting a …

Among the identified microRNAs (miRs) thus far,~ 50% of mammalian miRs are clustered in
the genome and transcribed as polycistronic primary transcripts. However, whether …

Ischemia-reperfusion injury (IRI) is a major causal factor of tissue injury in various clinical
settings including myocardial infarction, stroke, and free microsurgical tissue transfer …

Many small molecules (mostly lipids derived from polyunsaturated fatty acids) and proteins
(eg, cytokines and chemokines) are labeled as inflammatory mediators for their role in …

After spinal cord injury, dysregulated miRNAs appear and can participate in inflammatory
responses, as well as the inhibition of apoptosis and axon regeneration through multiple …

Although it is widely accepted that apoptosis may contribute to cell death in myocardial
infarction, experimental evidence suggests that adult cardiomyocytes repress the expression …

Executioner caspase-3 and-7 are proteases promoting cell death but non-apoptotic roles
are being discovered. The heart expresses caspases only during development, suggesting …

Recent clinical trials raised concerns regarding the cardiovascular toxicity of selective
cyclooxygenase-2 (COX-2) inhibitors and cyclooxygenase-1 (COX-1) is now being …