Measuring viscoelasticity of soft biological samples using atomic force microscopy

YM Efremov, T Okajima, A Raman - Soft matter, 2020 - pubs.rsc.org
Mechanical properties play important roles at different scales in biology. At the level of a
single cell, the mechanical properties mediate mechanosensing and mechanotransduction …

Probing soft matter with the atomic force microscopies: imaging and force spectroscopy

ME McConney, S Singamaneni, VV Tsukruk - Polymer Reviews, 2010 - Taylor & Francis
The development of atomic force microscopy has evolved into a wide variety of microscopy
and characterization techniques well beyond conventional imaging. The focus of this review …

Measuring nanoscale viscoelastic parameters of cells directly from AFM force-displacement curves

YM Efremov, WH Wang, SD Hardy, RL Geahlen… - Scientific reports, 2017 - nature.com
Abstract Force-displacement (FZ) curves are the most commonly used Atomic Force
Microscopy (AFM) mode to measure the local, nanoscale elastic properties of soft materials …

Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice

HIC Harn, SP Wang, YC Lai, B Van Handel… - Nature …, 2021 - nature.com
Tissue regeneration is a process that recapitulates and restores organ structure and
function. Although previous studies have demonstrated wound-induced hair neogenesis …

Mechanical regulation of nuclear structure and function

RP Martins, JD Finan, G Farshid… - Annual review of …, 2012 - annualreviews.org
Mechanical loading induces both nuclear distortion and alterations in gene expression in a
variety of cell types. Mechanotransduction is the process by which extracellular mechanical …

Microrheology and particle tracking in food gels and emulsions

T Moschakis - Current Opinion in Colloid & Interface Science, 2013 - Elsevier
Particle tracking microrheology, an emerging experimental technique, which utilizes the
Brownian motion of embedded particles to probe local dynamics of soft materials, is …

Benchtop technologies for circulating tumor cells separation based on biophysical properties

WS Low, WAB Wan Abas - BioMed research international, 2015 - Wiley Online Library
Circulating tumor cells (CTCs) are tumor cells that have detached from primary tumor site
and are transported via the circulation system. The importance of CTCs as prognostic …

When microrheology, bulk rheology, and microfluidics meet: Broadband rheology of hydroxyethyl cellulose water solutions

F Del Giudice, M Tassieri, C Oelschlaeger… - …, 2017 - ACS Publications
In this work, we present new insights related to a debate on the morphological structure of
hydroxyethyl cellulose (HEC) molecules when dissolved in water, ie, whether HEC adopts a …

Application of the Johnson–Kendall–Roberts model in AFM-based mechanical measurements on cells and gel.

YM Efremov, DV Bagrov, MP Kirpichnikov… - Colloids and Surfaces B …, 2015 - Elsevier
The force-distance curves (FCs) obtained by the atomic force microscope (AFM) with colloid
probes contain information about both the viscoelastic properties and adhesion of a sample …

Elastic properties of polystyrene nanospheres evaluated with atomic force microscopy: size effect and error analysis

D Guo, J Li, G Xie, Y Wang, J Luo - Langmuir, 2014 - ACS Publications
The mechanical properties of polystyrene (PS) nanospheres of ca. 50–1000 nm in diameter
were evaluated by using an atomic force microscope (AFM). The compressive elastic moduli …