[HTML][HTML] iPSC-derived natural killer cell therapies-expansion and targeting

BH Goldenson, P Hor, DS Kaufman - Frontiers in immunology, 2022 - frontiersin.org
Treatment of cancer with allogeneic natural killer (NK) cell therapies has seen rapid
development, especially use against hematologic malignancies. Clinical trials of NK cell …

[HTML][HTML] Cytokine-induced memory-like NK cells: from the basics to clinical applications

I Terrén, A Orrantia, G Astarloa-Pando… - Frontiers in …, 2022 - frontiersin.org
Natural killer (NK) cells are lymphocytes with a key role in the defense against viral
infections and tumor cells. Although NK cells are classified as innate lymphoid cells (ILCs) …

[HTML][HTML] Macrophage membrane-camouflaged shRNA and doxorubicin: a pH-dependent release system for melanoma chemo-immunotherapy

C Yang, Y Ming, K Zhou, Y Hao, D Hu, B Chu, X He… - Research, 2022 - spj.science.org
Improving the efficacy of melanoma treatment remains an important global challenge. Here,
we combined chemotherapy with protein tyrosine phosphatase nonreceptor type 2 (Ptpn2) …

[HTML][HTML] Shaping immune responses in the tumor microenvironment of ovarian cancer

X Luo, J Xu, J Yu, P Yi - Frontiers in immunology, 2021 - frontiersin.org
Reciprocal signaling between immune cells and ovarian cancer cells in the tumor
microenvironment can alter immune responses and regulate disease progression. These …

Immunotherapy for Ovarian Cancer: Disappointing or Promising?

M Deng, F Tang, X Chang, P Liu, X Ji… - Molecular …, 2024 - ACS Publications
Ovarian cancer, one of the deadliest malignancies, lacks effective treatment, despite
advancements in surgical techniques and chemotherapy. Thus, new therapeutic …

Chimeric antigen receptor natural killer cells: a promising antitumor immunotherapy

Y Wang, S Jin, Q Zhuang, N Liu, R Chen, SA Adam… - MedComm, 2023 - Wiley Online Library
Chimeric antigen receptor (CAR) T cells have been successfully used in adoptive cell
therapy for malignancies. However, some obstacles, including side effects such as graft …

The effect of mitochondria inhibition on natural killer cells cytotoxicity in triple-negative breast cancer cells

SH Khodaei, S Sabetnam, HN Charoudeh… - European Journal of …, 2023 - Elsevier
Abstract Triple-Negative Breast Cancer (TNBC), the most common invasive breast cancer,
depicts cancer poor response to conventional therapies. The clinical management of TNBC …

Nanomaterial‐Boosted Tumor Immunotherapy Through Natural Killer Cells

M Zhan, Y Guo, M Shen, X Shi - Advanced NanoBiomed …, 2022 - Wiley Online Library
Natural killer (NK)‐cell immunotherapy as an alternative to T‐cell immunotherapy has been
widely used in clinical cell immunotherapy of various tumors. Despite the surprising findings …

Patient-Specific Targeting of the T-Cell Receptor Variable Region as a Therapeutic Strategy in Clonal T-Cell Diseases

OM Lucero, JA Lee, J Bowman, K Johnson… - Clinical Cancer …, 2023 - AACR
Purpose: Targeted therapeutics are a goal of medicine. Methods for targeting T-cell
lymphoma lack specificity for the malignant cell, leading to elimination of healthy cells. The T …

[HTML][HTML] Adoptive cellular transfer Immunotherapies for cancer

P Parsonidis, I Papasotiriou - Cancer Treatment and Research …, 2022 - Elsevier
Patients with cancer require efficient treatment approaches as the mortality rate due to their
disease is high. Conventional therapies, like chemotherapy and radiation, have severe side …