The role of voltage-gated sodium channels in pain signaling
Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Cryo-EM in drug discovery: achievements, limitations and prospects
JP Renaud, A Chari, C Ciferri, W Liu… - Nature reviews Drug …, 2018 - nature.com
Cryo-electron microscopy (cryo-EM) of non-crystalline single particles is a biophysical
technique that can be used to determine the structure of biological macromolecules and …
technique that can be used to determine the structure of biological macromolecules and …
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
Membrane protein isolation and structure determination in cell-derived membrane vesicles
X Tao, C Zhao, R MacKinnon - Proceedings of the National …, 2023 - National Acad Sciences
Integral membrane protein structure determination traditionally requires extraction from cell
membranes using detergents or polymers. Here, we describe the isolation and structure …
membranes using detergents or polymers. Here, we describe the isolation and structure …
Structure of human Cav2.2 channel blocked by the painkiller ziconotide
The neuronal-type (N-type) voltage-gated calcium (Cav) channels, which are designated
Cav2. 2, have an important role in the release of neurotransmitters,–. Ziconotide is a Cav2. 2 …
Cav2. 2, have an important role in the release of neurotransmitters,–. Ziconotide is a Cav2. 2 …
Structural basis for high-voltage activation and subtype-specific inhibition of human Nav1.8
The dorsal root ganglia–localized voltage-gated sodium (Nav) channel Nav1. 8 represents a
promising target for developing next-generation analgesics. A prominent characteristic of …
promising target for developing next-generation analgesics. A prominent characteristic of …
Structural mapping of Nav1.7 antagonists
Voltage-gated sodium (Nav) channels are targeted by a number of widely used and
investigational drugs for the treatment of epilepsy, arrhythmia, pain, and other disorders …
investigational drugs for the treatment of epilepsy, arrhythmia, pain, and other disorders …
Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1
X Pan, Z Li, Q Zhou, H Shen, K Wu, X Huang, J Chen… - Science, 2018 - science.org
INTRODUCTION The nine subtypes of mammalian voltage-gated sodium (Nav) channels,
Nav1. 1 to Nav1. 9, are responsible for the initiation and propagation of action potentials in …
Nav1. 1 to Nav1. 9, are responsible for the initiation and propagation of action potentials in …
Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins
Voltage-gated sodium channel Nav1. 7 represents a promising target for pain relief. Here we
report the cryo–electron microscopy structures of the human Nav1. 7-β1-β2 complex bound …
report the cryo–electron microscopy structures of the human Nav1. 7-β1-β2 complex bound …
[HTML][HTML] Structure of the cardiac sodium channel
Voltage-gated sodium channel Na v 1.5 generates cardiac action potentials and initiates the
heartbeat. Here, we report structures of Na V 1.5 at 3.2–3.5 Å resolution. Na V 1.5 is …
heartbeat. Here, we report structures of Na V 1.5 at 3.2–3.5 Å resolution. Na V 1.5 is …