[HTML][HTML] Recent insights into mechanisms of β-cell lipo-and glucolipotoxicity in type 2 diabetes
The deleterious effects of chronically elevated free fatty acid (FFA) levels on glucose
homeostasis are referred to as lipotoxicity, and the concurrent exposure to high glucose may …
homeostasis are referred to as lipotoxicity, and the concurrent exposure to high glucose may …
Pancreatic regulation of glucose homeostasis
PV Röder, B Wu, Y Liu, W Han - Experimental & molecular medicine, 2016 - nature.com
In order to ensure normal body function, the human body is dependent on a tight control of
its blood glucose levels. This is accomplished by a highly sophisticated network of various …
its blood glucose levels. This is accomplished by a highly sophisticated network of various …
Evidence of β-cell dedifferentiation in human type 2 diabetes
F Cinti, R Bouchi, JY Kim-Muller… - The Journal of …, 2016 - academic.oup.com
Context: Diabetes is associated with a deficit of insulin-producing β-cells. Animal studies
show that β-cells become dedifferentiated in diabetes, reverting to a progenitor-like stage …
show that β-cells become dedifferentiated in diabetes, reverting to a progenitor-like stage …
The molecular link between oxidative stress, insulin resistance, and type 2 diabetes: A target for new therapies against cardiovascular diseases
Abstract Type 2 Diabetes Mellitus (T2D) is a chronic disease with a pandemic incidence
whose pathogenesis has not yet been clarified. Raising evidence highlighted the role of …
whose pathogenesis has not yet been clarified. Raising evidence highlighted the role of …
From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus
RA DeFronzo - Diabetes, 2009 - Am Diabetes Assoc
Insulin resistance in muscle and liver and-cell failure represent the core pathophysiologic
defects in type 2 diabetes. It now is recognized that the-cell failure occurs much earlier and …
defects in type 2 diabetes. It now is recognized that the-cell failure occurs much earlier and …
Utility of three novel insulin resistance‐related lipid indices for predicting type 2 diabetes mellitus among people with normal fasting glucose in rural China: 在空腹血糖 …
B Wang, M Zhang, Y Liu, X Sun, L Zhang… - Journal of …, 2018 - Wiley Online Library
摘要背景为了在中国农村地区早期预测2 型糖尿病(T2DM), 我们需要使用廉价且容易测量的
指标. 本研究旨在比较甘油三酯葡萄糖(riglyceride glucose, TyG), 内脏脂肪(visceral adiposity …
指标. 本研究旨在比较甘油三酯葡萄糖(riglyceride glucose, TyG), 内脏脂肪(visceral adiposity …
[HTML][HTML] Pathophysiologic approach to therapy in patients with newly diagnosed type 2 diabetes
RA DeFronzo, R Eldor, M Abdul-Ghani - Diabetes care, 2013 - ncbi.nlm.nih.gov
Two general approaches to the treatment of type 2 diabetes mellitus (T2DM) have been
advocated. 1) A “guideline” approach that advocates sequential addition of antidiabetes …
advocated. 1) A “guideline” approach that advocates sequential addition of antidiabetes …
[HTML][HTML] Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes
V Lyssenko, R Lupi, P Marchetti… - The Journal of …, 2007 - Am Soc Clin Investig
Transcription factor-7–like 2 (TCF7L2) is the most important type 2 diabetes susceptibility
gene identified to date, with common intronic variants strongly associated with diabetes in all …
gene identified to date, with common intronic variants strongly associated with diabetes in all …
[PDF][PDF] Obesity-associated low-grade inflammation in type 2 diabetes mellitus: causes and consequences
MM Van Greevenbroek, CG Schalkwijk, CD Stehouwer - Neth J Med, 2013 - njmonline.nl
The epidemic of overweight and obesity is a major problem because of the plethora of
health and economic issues that it induces. Key among these is the sharply increasing …
health and economic issues that it induces. Key among these is the sharply increasing …
Saturated fatty acids synergize with elevated glucose to cause pancreatic β-cell death
W El-Assaad, J Buteau, ML Peyot, C Nolan… - …, 2003 - academic.oup.com
We have proposed the “glucolipotoxicity” hypothesis in which elevated free fatty acids
(FFAs) together with hyperglycemia are synergistic in causing islet β-cell damage because …
(FFAs) together with hyperglycemia are synergistic in causing islet β-cell damage because …