The deleterious effects of chronically elevated free fatty acid (FFA) levels on glucose
homeostasis are referred to as lipotoxicity, and the concurrent exposure to high glucose may …

In order to ensure normal body function, the human body is dependent on a tight control of
its blood glucose levels. This is accomplished by a highly sophisticated network of various …

Context: Diabetes is associated with a deficit of insulin-producing β-cells. Animal studies
show that β-cells become dedifferentiated in diabetes, reverting to a progenitor-like stage …

Abstract Type 2 Diabetes Mellitus (T2D) is a chronic disease with a pandemic incidence
whose pathogenesis has not yet been clarified. Raising evidence highlighted the role of …

Insulin resistance in muscle and liver and-cell failure represent the core pathophysiologic
defects in type 2 diabetes. It now is recognized that the-cell failure occurs much earlier and …

摘要背景为了在中国农村地区早期预测2 型糖尿病(T2DM), 我们需要使用廉价且容易测量的
指标. 本研究旨在比较甘油三酯葡萄糖(riglyceride glucose, TyG), 内脏脂肪(visceral adiposity …

Two general approaches to the treatment of type 2 diabetes mellitus (T2DM) have been
advocated. 1) A “guideline” approach that advocates sequential addition of antidiabetes …

Transcription factor-7–like 2 (TCF7L2) is the most important type 2 diabetes susceptibility
gene identified to date, with common intronic variants strongly associated with diabetes in all …

The epidemic of overweight and obesity is a major problem because of the plethora of
health and economic issues that it induces. Key among these is the sharply increasing …

We have proposed the “glucolipotoxicity” hypothesis in which elevated free fatty acids
(FFAs) together with hyperglycemia are synergistic in causing islet β-cell damage because …