This Review is devoted to the chemistry of macrocyclic peptides having heterocyclic
fragments in their structure. These motifs are present in many natural products and synthetic …

Proteolytic enzymes are ubiquitous in all organisms and constitute 2–4% of the encoded
gene products. They are critical for diverse biological processes such as digestion, blood …

Understanding protein–protein interactions (PPIs) is quite important to elucidate crucial
biological processes and even design compounds that interfere with PPIs with …

The clinical utility of peptides is limited by their rapid degradation by endogenous proteases.
Modification of the peptide backbone can generate functional analogues with enhanced …

The lectin pathway is an antibody-independent activation route of the complement system. It
provides immediate defense against pathogens and altered self-cells, but it also causes …

Pancreatic chymotrypsins (CTRs) are digestive proteases that in humans include CTRB1,
CTRB2, CTRC, and CTRL. The highly similar CTRB1 and CTRB2 are the products of gene …

The vast majority of protein protease inhibitors bind their targets in a substrate-like manner.
This is a robust and efficient mechanism of inhibition but, due to the highly conserved …

Members of the pacifastin family are serine peptidase inhibitors, found in arthropods and
have many members within different insect orders. Based on their structural characteristics …

Cystine-dense peptides (CDPs) are a miniprotein class that can drug difficult targets with
high affinity and low immunogenicity. Tools for their design, however, are not as developed …

Proton affinity and p K a values of N-formyl-l-histidinamide are found to vary as a function of
its backbone and/or side-chain orientation. Proton affinities between the cationic and neutral …