The intestinal barrier protects the host against gut microbes, food antigens, and toxins
present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic …

Improved hygiene leading to reduced exposure to microorganisms has been implicated as
one possible cause for the recent “epidemic” of chronic inflammatory diseases (CIDs) in …

Time-restricted feeding (TRF) has recently gained interest as a potential anti-ageing
treatment for organisms from Drosophila to humans,,,–. TRF restricts food intake to specific …

Autophagy is a conserved process that catabolizes intracellular components to maintain
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …

The view that sleep is essential for survival is supported by the ubiquity of this behavior, the
apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep …

Levels of inflammatory mediators in circulation are known to increase with age, but the
underlying cause of this age-associated inflammation is debated. We find that, when …

Aging and diabetes mellitus are 2 well-known risk factors for cardiovascular disease (CVD).
During the past 50 years, there has been an dramatic increase in life expectancy with a …

The gastrointestinal tract has recently come to the forefront of multiple research fields. It is
now recognized as a major source of signals modulating food intake, insulin secretion and …

Humans share a core intestinal microbiome and yet human microbiome differs by genes,
species, enterotypes (ecology), and gene count (microbial diversity). Achievement of …

Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …