Fragile X syndrome (FXS), a heritable intellectual and autism spectrum disorder (ASD),
results from the loss of Fragile X mental retardation protein (FMRP). This …

RNA modifications regulate a variety of cellular processes including DNA repair. The RNA
methyltransferase TRDMT1 generates methyl-5-cytosine (m5C) on messenger RNA (mRNA) …

Intellectual disability (ID) and autism are hallmarks of Fragile X Syndrome (FXS), a
hereditary neurodevelopmental disorder. The gene responsible for FXS is Fragile X Mental …

DNA strand-breaks (SBs) with non-ligatable ends are generated by ionizing radiation,
oxidative stress, various chemotherapeutic agents, and also as base excision repair (BER) …

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by mutations in the
FMR1 gene and deficiency of a functional FMRP protein. FMRP is known as a translation …

Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an
untreatable autosomal dominant neurodegenerative disease, and the most common such …

Silencing of the fragile X mental retardation 1 (FMR1) gene and consequently lack of
synthesis of FMR protein (FMRP) are associated with fragile X syndrome, which is one of the …

Fragile X syndrome (FXS), the most common form of inherited cognitive disability, is caused
by a deficiency of the fragile X mental retardation protein (FMRP). In most patients, the …

The fragile X syndrome (FXS) arises from loss of expression or function of the FMR1 gene
and is one of the most common monogenic forms of intellectual disability and autism. During …

For many years, epidemiological studies have suggested an association between cancer
and neurodegenerative disorders—two disease processes that seemingly have little in …