Mesenchymal Stem Cell‐derived Exosomes: Novel Therapeutic Approach for Inflammatory Bowel Diseases

C Tian, M Yang, H Xu, M Zhu, Y Zhang… - Stem cells …, 2023 - Wiley Online Library
As double membrane‐encapsulated nanovesicles (30‐150 nm), exosomes (Exos) shuttle
between different cells to mediate intercellular communication and transport active cargoes …

A systematic review and meta‐analysis of clinical trials assessing safety and efficacy of human extracellular vesicle‐based therapy

M Van Delen, J Derdelinckx, K Wouters… - Journal of …, 2024 - Wiley Online Library
Nowadays, it has become clear that extracellular vesicles (EVs) are not a cellular waste
disposal vesicle but are an essential part of an intercellular communication system. Besides …

[HTML][HTML] Adipose tissue-derived mesenchymal stem cell-derived exosomes promote wound healing and tissue regeneration

JH Lee, YJ Won, H Kim, M Choi, E Lee… - International Journal of …, 2023 - mdpi.com
Wound healing is a complex process involving cell proliferation, migration, and extracellular
matrix (ECM) remodeling. Extracellular vesicles (EVs) or exosomes derived from adipose …

Safety and efficacy of injection of human placenta mesenchymal stem cells derived exosomes for treatment of complex perianal fistula in non‐Crohn's cases: Clinical …

H Pak, A Hadizadeh, A Heirani‐Tabasi… - Journal of …, 2023 - Wiley Online Library
Background and Aim A perianal fistula is an abnormal tract that connects anal canal to skin.
Current medical and surgical interventions have a high failure rate particularly in complex …

[HTML][HTML] Exosome-based crosstalk in glaucoma pathogenesis: a focus on oxidative stress and neuroinflammation

L Wang, X Wei - Frontiers in Immunology, 2023 - frontiersin.org
Exosomes are membrane-bound tiny particles that are released by all live cells that contain
multiple signal molecules and extensively participate in numerous normal physical activities …

Double‐Layer Asymmetric Porous Mesh with Dynamic Mechanical Support Properties Enables Efficient Single‐Stage Repair of Contaminated Abdominal Wall Defect

F Tang, D Miao, R Huang, B Zheng, Y Yu… - Advanced …, 2024 - Wiley Online Library
Contamination tolerance and long‐term mechanical support are the two critical properties of
meshes for contaminated abdominal wall defect repair. However, biological meshes with …

Exosomes for angiogenesis induction in ischemic disorders

K Moeinabadi‐Bidgoli, M Rezaee… - Journal of cellular …, 2023 - Wiley Online Library
Ischaemic disorders are leading causes of morbidity and mortality worldwide. While the
current therapeutic approaches have improved life expectancy and quality of life, they are …

[HTML][HTML] A roadmap from research to clinical testing of mesenchymal stromal cell exosomes in the treatment of psoriasis

RC Lai, TT Tan, WK Sim, B Zhang, SK Lim - Cytotherapy, 2023 - Elsevier
The most clinically trialed cells, mesenchymal stromal cells (MSCs), are now known to
mainly exert their therapeutic activity through paracrine secretions, which include exosomes …

Engineered stem cell-based strategy: A new paradigm of next-generation stem cell product in regenerative medicine

H Han, BT Chen, Y Liu, Y Wang, L Xing, H Wang… - Journal of Controlled …, 2024 - Elsevier
Stem cells have garnered significant attention in regenerative medicine owing to their
abilities of multi-directional differentiation and self-renewal. Despite these encouraging …

[HTML][HTML] Advances in the application of extracellular vesicles derived from three-dimensional culture of stem cells

W Chen, P Wu, C Jin, Y Chen, C Li, H Qian - Journal of …, 2024 - Springer
Stem cells (SCs) have been used therapeutically for decades, yet their applications are
limited by factors such as the risk of immune rejection and potential tumorigenicity …