Design and validation of diffusion MRI models of white matter

IO Jelescu, MD Budde - Frontiers in physics, 2017 - frontiersin.org
Diffusion MRI is arguably the method of choice for characterizing white matter microstructure
in vivo. Over the typical duration of diffusion encoding, the displacement of water molecules …

[HTML][HTML] Challenges for biophysical modeling of microstructure

IO Jelescu, M Palombo, F Bagnato… - Journal of Neuroscience …, 2020 - Elsevier
The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25
years. In this review, we dwell on the various challenges along the journey of bringing a …

Degeneracy in model parameter estimation for multi‐compartmental diffusion in neuronal tissue

IO Jelescu, J Veraart, E Fieremans… - NMR in …, 2016 - Wiley Online Library
The ultimate promise of diffusion MRI (dMRI) models is specificity to neuronal microstructure,
which may lead to distinct clinical biomarkers using noninvasive imaging. While multi …

Learning in the fast lane: new insights into neuroplasticity

Y Sagi, I Tavor, S Hofstetter, S Tzur-Moryosef… - Neuron, 2012 - cell.com
The timescale of structural remodeling that accompanies functional neuroplasticity is largely
unknown. Although structural remodeling of human brain tissue is known to occur following …

Diffusion MRI at 25: exploring brain tissue structure and function

D Le Bihan, H Johansen-Berg - Neuroimage, 2012 - Elsevier
Diffusion MRI (or dMRI) came into existence in the mid-1980s. During the last 25years,
diffusion MRI has been extraordinarily successful (with more than 300,000 entries on …

Usefulness of diffusion‐weighted MRI with echo‐planar technique in the evaluation of cellularity in gliomas

T Sugahara, Y Korogi, M Kochi… - Journal of Magnetic …, 1999 - Wiley Online Library
The purpose of this study was to evaluate the utility of diffusion‐weighted magnetic
resonance imaging (MRI) with echo‐planar imaging (EPI) technique in depicting the tumor …

Viability thresholds and the penumbra of focal ischemia

KA Hossmann - Annals of Neurology: Official Journal of the …, 1994 - Wiley Online Library
The classic concept of the viability thresholds of ischemia differentiates between two critical
flow rates, the threshold of electrical failure and the threshold of membrane failure. These …

Diffusion-weighted MR imaging of the brain

PW Schaefer, PE Grant, RG Gonzalez - Radiology, 2000 - pubs.rsna.org
Diffusion-weighted magnetic resonance (MR) imaging provides image contrast that is
different from that provided by conventional MR techniques. It is particularly sensitive for …

Fast magnetic resonance diffusion‐weighted imaging of acute human stroke

S Warach, D Chien, W Li, M Ronthal, RR Edelman - Neurology, 1992 - AAN Enterprises
Rapid MRI of the molecular diffusion of water demonstrated cerebral infarcts in 32 patients.
We studied these patients at various times following the onset of ischemic symptoms and …

Acute human stroke studied by whole brain echo planar diffusion‐weighted magnetic resonance imaging

S Warach, J Gaa, B Siewert… - Annals of Neurology …, 1995 - Wiley Online Library
Our purpose was to use whole brain echo planar magnetic resonance imaging (MRI) to
identify and characterize diffusion abnormalities in acute cerebral ischemia. We studied 40 …