Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

Bile acids (BAs) are amphipathic steroid acids whose production and diversity depend on
both host and microbial metabolism. These metabolites have emerged as biologically active …

Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence
has increased globally since the 1970s, and the number of obese and overweight people is …

Changes in microbial diversity and composition are increasingly associated with several
disease states including obesity and behavioural disorders. Obesity-associated microbiota …

The gut microbiota is considered a metabolic" organ" that not only facilitates harvesting of
nutrients and energy from the ingested food but also produces numerous metabolites that …

Bile acids (BAs) are cholesterol-derived metabolites that facilitate the intestinal absorption
and transport of dietary lipids. Recently, BAs also emerged as pivotal signaling molecules …

Introduction Establishing whether specific structural and functional configurations of a
human gut microbiota are causally related to a given physiologic or disease phenotype is …

FXR agonists are used to treat non-alcoholic fatty liver disease (NAFLD), in part because
they reduce hepatic lipids. Here, we show that FXR activation with the FXR agonist …

The intestinal reclamation of bile acids is crucial for the maintenance of their enterohepatic
circulation. The majority of bile acids are actively absorbed via specific transport proteins …

The liver is the central metabolic hub which coordinates nutritional inputs and metabolic
outputs. Food intake releases bile acids which can be sensed by the bile acid receptor FXR …