Therapeutic implications of tumor microenvironment in lung cancer: focus on immune checkpoint blockade
C Genova, C Dellepiane, P Carrega… - Frontiers in …, 2022 - frontiersin.org
In the last decade, the treatment of non-small cell lung cancer (NSCLC) has been
revolutionized by the introduction of immune checkpoint inhibitors (ICI) directed against …
revolutionized by the introduction of immune checkpoint inhibitors (ICI) directed against …
Biological characteristics and clinical significance of soluble PD-1/PD-L1 and exosomal PD-L1 in cancer
M Niu, Y Liu, M Yi, D Jiao, K Wu - Frontiers in Immunology, 2022 - frontiersin.org
The immune checkpoint pathway consisting of the cell membrane-bound molecule
programmed death protein 1 (PD-1) and its ligand PD-L1 has been found to mediate …
programmed death protein 1 (PD-1) and its ligand PD-L1 has been found to mediate …
TGF-β: A novel predictor and target for anti-PD-1/PD-L1 therapy
Transforming growth factor-β (TGF-β) signaling regulates multiple physiological processes,
such as cell proliferation, differentiation, immune homeostasis, and wound healing. Besides …
such as cell proliferation, differentiation, immune homeostasis, and wound healing. Besides …
Predictive biomarkers of anti-PD-1/PD-L1 therapy in NSCLC
M Niu, M Yi, N Li, S Luo, K Wu - Experimental hematology & oncology, 2021 - Springer
Immunotherapy, especially anti-programmed cell death protein 1/programmed cell death
ligand 1 (PD-1/PD-L1) treatment has significantly improved the survival of non-small cell …
ligand 1 (PD-1/PD-L1) treatment has significantly improved the survival of non-small cell …
Macrophage-related SPP1 as a potential biomarker for early lymph node metastasis in lung adenocarcinoma
B Dong, C Wu, L Huang, Y Qi - Frontiers in cell and developmental …, 2021 - frontiersin.org
Lymph node metastasis is a major factor that affects prognosis in patients with lung
adenocarcinoma (LUAD). In some cases, lymph node metastasis has already occurred …
adenocarcinoma (LUAD). In some cases, lymph node metastasis has already occurred …
[HTML][HTML] Identification and integration analysis of a novel prognostic signature associated with cuproptosis-related ferroptosis genes and relevant lncRNA regulatory …
T Wang, X Jiang, Y Lu, Y Ruan, J Wang - Aging (albany NY), 2023 - ncbi.nlm.nih.gov
Lung adenocarcinoma (LUAD) is a highly prevalent malignancy worldwide, and its clinical
prognosis assessment and treatment is a major research direction. Both ferroptosis and …
prognosis assessment and treatment is a major research direction. Both ferroptosis and …
[HTML][HTML] The role of neoantigens in tumor immunotherapy
S Shang, Y Zhao, K Qian, Y Qin, X Zhang, T Li… - Biomedicine & …, 2022 - Elsevier
Tumor neoantigens are aberrant polypeptides produced by tumor cells as a result of
genomic mutations. They are also tumor-specific antigens (TSA). Neoantigens are more …
genomic mutations. They are also tumor-specific antigens (TSA). Neoantigens are more …
[HTML][HTML] Manipulating TGF-β signaling to optimize immunotherapy for cervical cancer
S Yin, H Cui, S Qin, S Yu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Cervical cancer is a serious threat to women's health globally. Therefore, identifying key
molecules associated with cervical cancer progression is essential for drug development …
molecules associated with cervical cancer progression is essential for drug development …
[HTML][HTML] Development and validation of a DNA methylation-related classifier of circulating tumour cells to predict prognosis and to provide a therapeutic strategy in …
X Gu, X Huang, X Zhang, C Wang - International Journal of …, 2022 - ncbi.nlm.nih.gov
Background: A significant factor influencing the prognosis of lung adenocarcinoma (LUAD)
is tumor metastasis. Studies have shown that abnormal DNA methylation in circulating tumor …
is tumor metastasis. Studies have shown that abnormal DNA methylation in circulating tumor …
Integration of single-cell RNA sequencing and bulk RNA sequencing data to establish and validate a prognostic model for patients with lung adenocarcinoma
A Jiang, J Wang, N Liu, X Zheng, Y Li, Y Ma… - Frontiers in …, 2022 - frontiersin.org
Background: Lung adenocarcinoma (LUAD) remains a lethal disease worldwide, with
numerous studies exploring its potential prognostic markers using traditional RNA …
numerous studies exploring its potential prognostic markers using traditional RNA …