Hirschsprung disease (HSCR) is the leading cause of neonatal functional intestinal
obstruction. It is a rare congenital disease with an incidence of one in 3,500–5,000 live …

Hirschsprung's disease (HSCR) is a classical model of enteric neuropathy, occurring in
approximately 2–2.8 in 10,000 newborns. It is the commonest form of congenital bowel …

Background & Aims Hirschsprung disease (HSCR) is a life-threatening birth defect in which
the distal colon is devoid of enteric neural ganglia. HSCR is treated by surgical removal of …

Hirschsprung disease (HSCR) is the most frequent developmental anomaly of the enteric
nervous system, with an incidence of 1 in 5000 live births. Chronic intestinal pseudo …

The development of the enteric nervous system (ENS) is highly modulated by the
synchronized interaction between the enteric neural crest cells (ENCCs) and the neural …

Hirschsprung disease is a neurocristopathy, characterized by aganglionosis in the distal
bowel. It is caused by failure of the enteric nervous system progenitors to migrate, proliferate …

Hirschsprung disease (HSCR) is a rare congenital disorder caused by an incorrect enteric
nervous system development due to a failure in migration, proliferation, differentiation and/or …

The nutritional requirements of the developing embryo are complex. In the case of dietary
vitamin A (retinol, retinyl esters and provitamin A carotenoids), maternal derived nutrients …

Retinoic acid (RA) signaling is essential for enteric nervous system (ENS) development,
since vitamin A deficiency or mutations in RA signaling profoundly reduce bowel …

TRiC/CCT is a chaperonin complex required for the folding of cytoplasmic proteins. Although
mutations in each subunit of TRiC/CCT are associated with various human …