Structures and functions of cilia during vertebrate embryo development

JD Amack - Molecular reproduction and development, 2022 - Wiley Online Library
Cilia are hair‐like structures that project from the surface of cells. In vertebrates, most cells
have an immotile primary cilium that mediates cell signaling, and some specialized cells …

Advances in dyslexia genetics—new insights into the role of brain asymmetries

S Paracchini, R Diaz, J Stein - Advances in genetics, 2016 - Elsevier
Dyslexia is a common condition affecting up to 10% school-aged children. There is strong
evidence that genetics plays an important role in dyslexia and is expected to be complex in …

Rab35 controls cilium length, function and membrane composition

S Kuhns, C Seixas, S Pestana, B Tavares… - EMBO …, 2019 - embopress.org
Rab and Arl guanine nucleotide‐binding (G) proteins regulate trafficking pathways essential
for the formation, function and composition of primary cilia, which are sensory devices …

Physical limits of flow sensing in the left-right organizer

RR Ferreira, A Vilfan, F Jülicher, W Supatto, J Vermot - Elife, 2017 - elifesciences.org
Fluid flows generated by motile cilia are guiding the establishment of the left-right asymmetry
of the body in the vertebrate left-right organizer. Competing hypotheses have been …

Functional characterization of tektin-1 in motile cilia and evidence for TEKT1 as a new candidate gene for motile ciliopathies

R Ryan, M Failler, ML Reilly… - Human Molecular …, 2018 - academic.oup.com
A child presenting with Mainzer-Saldino syndrome (MZSDS), characterized by renal, retinal
and skeletal involvements, was also diagnosed with lung infections and airway ciliary …

Symmetry-breaking cilia-driven flow in embryogenesis

DJ Smith, TD Montenegro-Johnson… - Annual Review of Fluid …, 2019 - annualreviews.org
The systematic breaking of left–right body symmetry is a familiar feature of human
physiology. In humans and many animals, this process originates with asymmetric fluid flow …

Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer

B Tavares, R Jacinto, P Sampaio, S Pestana, A Pinto… - Elife, 2017 - elifesciences.org
Foxj1a is necessary and sufficient to specify motile cilia. Using transcriptional studies and
slow-scan two-photon live imaging capable of identifying the number of motile and immotile …

Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes

SJ England, PC Campbell, S Banerjee… - Frontiers in Cell and …, 2017 - frontiersin.org
Polycystic kidney disease (PKD) proteins are trans-membrane proteins that have crucial
roles in many aspects of vertebrate development and physiology, including the development …

Dynamics of cilia length in left–right development

P Pintado, P Sampaio, B Tavares… - Royal Society …, 2017 - royalsocietypublishing.org
Reduction in the length of motile cilia in the zebrafish left–right organizer (LRO), also known
as Kupffer's vesicle, has a large impact on left–right development. Here we demonstrate …

Analysis of cilia structure and function in zebrafish

E Leventea, K Hazime, C Zhao, J Malicki - Methods in Cell Biology, 2016 - Elsevier
Cilia are microtubule-based protrusions on the surface of most eukaryotic cells. They are
found in most, if not all, vertebrate organs. Prominent cilia form in sensory structures, the …