Abstract Lynch, MA. Long-Term Potentiation and Memory. Physiol Rev 84: 87–136, 2004;
10.1152/physrev. 00014.2003.—One of the most significant challenges in neuroscience is to …

Protein phosphatase 1 (PP1) is a major eukaryotic protein serine/threonine phosphatase
that regulates an enormous variety of cellular functions through the interaction of its catalytic …

Ceulemans, Hugo, and Mathieu Bollen. Functional Diversity of Protein Phosphatase-1, a
Cellular Economizer and Reset Button. Physiol Rev 84: 1–39, 2004; 10.1152/physrev …

Learning and memory require the formation of new neural networks in the brain. A key
mechanism underlying this process is synaptic plasticity at excitatory synapses, which …

The threshold for hippocampal-dependent synaptic plasticity and memory storage is thought
to be determined by the balance between protein phosphorylation and dephosphorylation …

The growth arrest and DNA damage-inducible protein, GADD34, was identified by its
interaction with human inhibitor 1 (I-1), a protein kinase A (PKA)-activated inhibitor of type 1 …

A prominent role for calcium/calmodulin-dependent protein kinase II (CaMKII) in regulation
of excitatory synaptic transmission was proposed two decades ago when it was identified as …

The regulation of glutamate-mediated excitatory neurotransmission has a critical role in
many aspects of behaviour. Great effort has gone into understanding the signal transduction …

Increases in type 1 phosphatase (PP1) activity have been observed in end stage human
heart failure, but the role of this enzyme in cardiac function is unknown. To elucidate the …

The sympathetic nervous system provides the most powerful stimulation of cardiac function,
brought about via norepinephrine and epinephrine and their postsynaptic β-adrenergic …