Current clinical approaches to osteoporosis primarily target osteoclast biology, overlooking
the synergistic role of bone cells, immune cells, cytokines, and inorganic components in …

A third of the population sustains a bone fracture, and the pace of fracture healing slows with
age. The slower pace of repair is responsible for the increased morbidity in older individuals …

Osteoarthritis (OA) is the most common arthritis with a rapidly increasing prevalence.
Disease progression is irreversible, and there is no curative therapy available. During OA …

The actin-bundling protein L-plastin (LPL) mediates the resorption activity of osteoclasts, but
its therapeutic potential in pathological bone loss remains unexplored. Here, we report that …

As the population ages, more and more people are suffering from osteoarthritis (OA),
resulting in an increasing requirement for joint implants. Surface modification to improve the …

Inflammation-associated proteinase functions are key determinants of inflammatory stromal
tissues deconstruction. As a specialized inflammatory pathological process, dental internal …

Cathepsin K (CatK), an essential collagenase in osteoclasts (OCs), is a potential therapeutic
target for the treatment of osteoporosis. Using live-cell imaging, we monitored the bone …

Osteoclasts are multinucleated cells of hematopoietic origin which are critically involved in
physiological and pathological bone resorption. They develop from myeloid progenitors …

The chapter also discusses the location, tissue structure of parathyroid glands, and
important functions of PTH. PTH performs its functions in coordination with calcitonin and the …

The TAM family of receptor tyrosine kinases were recently identified to regulate bone
homeostasis by controlling osteoblasts and bone formation. Despite extensive knowledge of …