Mechanobiologic signals regulate cellular responses under physiologic and pathologic
conditions. Using synthetic biology and tissue engineering, we developed a mechanically …

Renal cystogenesis is the pathological hallmark of autosomal dominant polycystic kidney
disease, caused by PKD1 and PKD2 mutations. The formation of renal cysts is a common …

The specialized pericellular matrix (PCM) surrounding chondrocytes within articular
cartilage is critical to the tissue's health and longevity. Growing evidence suggests that PCM …

Atrioventricular valve regurgitation is a significant cause of morbidity and mortality in patients
with acquired and congenital cardiac valve disease. Image-derived computational modeling …

A cell's ability to change shape is one of the most fundamental biological processes and is
essential for maintaining healthy organisms. When the ability to control shape goes awry, it …

Recent in vivo and in vitro studies have demonstrated that superficial zone (SZ)
chondrocytes within articular layers of diarthrodial joints die under normal physiologic …

Mathematical and computational models linking cell mechanical properties with deformation
are crucial for understanding cellular behavior. While various techniques measure the …

Probing mechanical properties of cells has been identified as a means to infer information
on their current state, eg with respect to diseases or differentiation. Oocytes have gained …

Mixture theory is a general framework that has been used to model mixtures of solid, fluid,
and solute constituents, leading to significant advances in modeling the mechanics of …

Advances in three-dimensional imaging provide the ability to construct and analyze finite
element (FE) models to evaluate the biomechanical behavior and function of atrioventricular …