Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …

Macrophages are essential for the maintenance of intestinal homeostasis, yet appear to be
drivers of inflammation in the context of inflammatory bowel disease (IBD). How these …

The triggering receptor expressed on myeloid cells-1 (TREM-1) is a pro-inflammatory
immune receptor potentiating acute lung injury (ALI). However, the mechanism of TREM-1 …

Gas exchange is the vital function of the lungs. It occurs in the alveoli, where oxygen and
carbon dioxide diffuse across the alveolar epithelium and the capillary endothelium …

Acute respiratory distress syndrome (ARDS) is defined as a syndrome of acute onset, with
bilateral opacities on chest imaging and respiratory failure not caused by cardiac failure …

Myeloid cells in the tumor microenvironment (TME) can exist in immunosuppressive and
immunostimulatory states that impede or promote antitumor immunity, respectively. Blocking …

Platelets are small circulating anucleate cells that are of crucial importance in haemostasis.
Over the last decade, it has become increasingly clear that platelets play an important role in …

The triggering receptor expressed on myeloid cell 1 (TREM1) plays a critical role in
development of chronic inflammatory disorders and the inflamed tumor microenvironment …

Triggering receptor expressed on myeloid cells-1 (TREM-1) is expressed on the majority of
innate immune cells and to a lesser extent on parenchymal cells. Upon activation, TREM-1 …

Objective Although anti-tumour necrosis factor alpha (anti-TNFα) therapies represent a
major breakthrough in IBD therapy, their cost–benefit ratio is hampered by an overall 30 …