Insulin signal transduction perturbations in insulin resistance
Type 2 diabetes mellitus is a widespread medical condition, characterized by high blood
glucose and inadequate insulin action, which leads to insulin resistance. Insulin resistance …
glucose and inadequate insulin action, which leads to insulin resistance. Insulin resistance …
Inositol Pyrophosphates as Versatile Metabolic Messengers
Discovered in 1993, inositol pyrophosphates are evolutionarily conserved signaling
metabolites whose versatile modes of action are being increasingly appreciated. These …
metabolites whose versatile modes of action are being increasingly appreciated. These …
Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1, 5-IP8 and the SPX domain of Pho81
Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient
with its negative bioenergetic impact on reactions liberating phosphate. Phosphate …
with its negative bioenergetic impact on reactions liberating phosphate. Phosphate …
Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues
Technical challenges have to date prevented a complete profiling of the levels of myo-
inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) in mammalian tissues. Here, we …
inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) in mammalian tissues. Here, we …
[HTML][HTML] Versatile signaling mechanisms of inositol pyrophosphates
MN Trung, D Furkert, D Fiedler - Current opinion in chemical biology, 2022 - Elsevier
Inositol pyrophosphates (PP-InsPs) constitute a group of highly charged messengers, which
regulate central biological processes in health and disease, such as cellular phosphate and …
regulate central biological processes in health and disease, such as cellular phosphate and …
Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus
G Zong, Y Desfougères, P Portela-Torres… - The EMBO …, 2024 - embopress.org
Kinases that synthesize inositol phosphates (IPs) and pyrophosphates (PP-IPs) control
numerous biological processes in eukaryotic cells. Herein, we extend this cellular signaling …
numerous biological processes in eukaryotic cells. Herein, we extend this cellular signaling …
Phosphate homeostasis− a vital metabolic equilibrium maintained through the INPHORS signaling pathway
S Austin, A Mayer - Frontiers in Microbiology, 2020 - frontiersin.org
Cells face major changes in demand for and supply of inorganic phosphate (Pi). Pi is often a
limiting nutrient in the environment, particularly for plants and microorganisms. At the same …
limiting nutrient in the environment, particularly for plants and microorganisms. At the same …
[HTML][HTML] Inositol phosphate kinases in the eukaryote landscape
D Laha, P Portela-Torres, Y Desfougères… - Advances in biological …, 2021 - Elsevier
Inositol phosphate encompasses a large multifaceted family of signalling molecules that
originate from the combinatorial attachment of phosphate groups to the inositol ring. To date …
originate from the combinatorial attachment of phosphate groups to the inositol ring. To date …
IP8: A quantitatively minor inositol pyrophosphate signaling molecule that punches above its weight
The inositol pyrophosphates (PP-IPs) are specialized members of the wider inositol
phosphate signaling family that possess functionally significant diphosphate groups. The PP …
phosphate signaling family that possess functionally significant diphosphate groups. The PP …
Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of pho1 Gene …
Inositol pyrophosphates (IPPs) are signaling molecules that regulate cellular phosphate
homeostasis in diverse eukaryal taxa. In fission yeast, mutations that increase 1, 5-IP8 …
homeostasis in diverse eukaryal taxa. In fission yeast, mutations that increase 1, 5-IP8 …