Osteoclasts and osteoblasts dictate skeletal mass, structure, and strength via their respective
roles in resorbing and forming bone. Bone remodeling is a spatially coordinated lifelong …

The past decade has seen an explosion in the field of bone biology. The area of bone
biology over this period of time has been marked by a number of key discoveries that have …

Bone metastatic lesions are classified as osteoblastic or osteolytic lesions. Prostate and
breast cancer patients frequently exhibit osteoblastic-type and osteolytic-type bone …

Oncogenic events combined with a favourable environment are the two main factors in the
oncological process. The tumour microenvironment is composed of a complex …

Production of the cytokine receptor activator of NFκB ligand (RANKL) by lymphocytes has
been proposed as a mechanism by which sex steroid deficiency causes bone loss …

Context: Receptor activator of nuclear factor-κB ligand (RANKL), receptor activator of
nuclear factor-κB (RANK), and osteoprotegerin (OPG) play a central role in bone remodeling …

Osteoclasts are primary cells for physiological and pathological bone resorption, and
receptor activator of nuclear factor‐κB ligand (RANKL) is critically involved in the …

Osteoclasts are myeloid lineage-derived bone-resorbing cells of hematopoietic origin. They
differentiate from myeloid precursors through a complex regulation process where the …

BACKGROUND Late‐stage prostate cancer patients are refractory to hormone therapy and
exhibit a high propensity to develop skeletal metastasis. In this regard, the role of a novel …

Osteolytic bone disease in multiple myeloma (MM) is caused by enhanced osteoclast (OCL)
activation and inhibition of osteoblast function. Lenalidomide and bortezomib have shown …