Actin participates in more protein–protein interactions than any other known protein,
including the interaction of actin with itself to form the helical polymer F-actin. The vast …

Axonal injury and degeneration, whether primary or secondary, contribute to the morbidity
and mortality seen in many acquired and inherited central nervous system (CNS) and …

Actin has maintained an exquisite degree of sequence conservation over large evolutionary
distances for reasons that are not understood. The desire to explain phenomena from …

Actins are highly conserved proteins and key players in central processes in all eukaryotic
cells. The two actins of the malaria parasite are among the most divergent eukaryotic actins …

Tropomyosin is a major regulatory protein of contractile systems and cytoskeleton, an actin-
binding protein that positions laterally along actin filaments and modulates actin–myosin …

Plasmodium falciparum, the etiologic agent of malaria, is a facultative intracellular parasite
of the phylum Apicomplexa. A limited turnover of microfilaments takes place beneath the …

Essential cellular processes involving the actin cytoskeleton are regulated by auxiliary
proteins that can sense the nucleotide state of actin. Here we report cryo-EM structures for …

Actin is one of the most abundant proteins in nature. It is found in all eukaryotes and plays a
fundamental role in many diverse and dynamic cellular processes. Also, actin is one of the …

Earlier, we have shown that spontaneously isolated non‐pathogenic bacteria Serratia
grimesii and Serratia proteamaculans invade eukaryotic cells, provided that they synthesize …

Conformational changes induced by ATP hydrolysis on actin are involved in the regulation
of complex actin networks. Previous structural and biochemical data implicate the DNase I …