Insulin plays a central role in the regulation of human metabolism. The hormone is a 51-
residue anabolic protein that is secreted by the β-cells in the Islets of Langerhans …

Progress in solving the structure of insulin bound to its receptor has been slow and stepwise,
but a milestone has now been reached with a refined structure of a complex of insulin with a …

Insulin receptor signalling has a central role in mammalian biology, regulating cellular
metabolism, growth, division, differentiation and survival,. Insulin resistance contributes to …

Insulin, a key peptide hormone that conjointly with its receptor regulates blood glucose
levels, is used as the major means to treat diabetes. This therapeutic hormone may undergo …

The insulin receptor isoform A (IR-A) binds both insulin and insulin-like growth factor (IGF)-II,
although the affinity for IGF-II is 3–10-fold lower than insulin depending on a cell and tissue …

Chemical and enzymatic modifications of peptide-displayed libraries have been successfully
employed to expand the phage display library. However, the requirement of specific …

Insulin is a lifesaver for millions of diabetic patients. There is a need for new insulin
analogues with more physiological profiles and analogues that will be thermally more stable …

Insulin is a key protein hormone that regulates blood glucose levels and, thus, has
widespread impact on lipid and protein metabolism. Insulin action is manifested through …

Crystallographic studies of insulin bound to receptor domains have defined the primary
hormone-receptor interface. We investigated the role of Tyr B26, a conserved aromatic …

The N-terminus of the B-chain of insulin may adopt two alternative conformations designated
as the T-and R-states. Despite the recent structural insight into insulin–insulin receptor (IR) …