[HTML][HTML] Topical insulin in neurotrophic keratopathy: a review of current understanding of the mechanism of action and therapeutic approach
M Jaworski, A Lorenc, R Leszczyński… - Pharmaceutics, 2023 - mdpi.com
Neurotrophic keratopathy is a corneal disease characterized by impaired corneal
innervation. It can lead to corneal epithelial defects, ulcerations, and perforations. Topical …
innervation. It can lead to corneal epithelial defects, ulcerations, and perforations. Topical …
[HTML][HTML] New developments in the management of persistent corneal epithelial defects
A persistent epithelial defect (PED) is a corneal epithelial defect that failed to heal after 2
weeks. It is a condition that carries much morbidity, and our understanding of PED remains …
weeks. It is a condition that carries much morbidity, and our understanding of PED remains …
[HTML][HTML] Comprehensive dry eye therapy: overcoming ocular surface barrier and combating inflammation, oxidation, and mitochondrial damage
Y Xia, Y Zhang, Y Du, Z Wang, L Cheng… - Journal of …, 2024 - Springer
Abstract Background Dry Eye Disease (DED) is a prevalent multifactorial ocular disease
characterized by a vicious cycle of inflammation, oxidative stress, and mitochondrial …
characterized by a vicious cycle of inflammation, oxidative stress, and mitochondrial …
The role of topical insulin in ocular surface restoration: A review
I Krolo, J Behaegel, K Termote, B de Bruyn… - Survey of …, 2024 - Elsevier
Corneal epithelial defects are one of the most common ocular disorders. Restoring corneal
integrity is crucial to reduce pain and regain function, but in cases of neurotrophic or …
integrity is crucial to reduce pain and regain function, but in cases of neurotrophic or …
Combined use of therapeutic hyper-CL soft contact lens and insulin eye drops for the treatment of recalcitrant neurotrophic keratopathy
G Giannaccare, G Coco, C Rossi, M Borselli… - Cornea, 2022 - journals.lww.com
Purpose: The aim of this study was to report the successful clinical outcome of recalcitrant
neurotrophic keratopathy (NK) treated with insulin eye drops associated with therapeutic …
neurotrophic keratopathy (NK) treated with insulin eye drops associated with therapeutic …
Topical Insulin Eye Drops: Stability and Safety of Two Compounded Formulations for Treating Persistent Corneal Epithelial Defects
M Vicario-de-la-Torre, V Puebla-García… - Pharmaceutics, 2024 - mdpi.com
Compounded insulin eye drops were prepared at 1 IU/mL from commercially available
subcutaneous insulin by dilution in saline solution or artificial tears. Physicochemical …
subcutaneous insulin by dilution in saline solution or artificial tears. Physicochemical …
[HTML][HTML] The Role of Insulin-like Growth Factor (IGF) System in the Corneal Epithelium Homeostasis—From Limbal Epithelial Stem Cells to Therapeutic Applications
M Woronkowicz, H Roberts, P Skopiński - Biology, 2024 - mdpi.com
Simple Summary The corneal epithelium is a protective barrier and refractive structure in the
eye maintained through a complex regenerative process involving the lacrimal gland, tear …
eye maintained through a complex regenerative process involving the lacrimal gland, tear …
Topical Insulin for Ocular Surface Disease
P Cid-Bertomeu, M Vilaltella, M Martínez… - Journal of Ocular …, 2024 - liebertpub.com
Background: Insulin and insulin-like growth factor (IGF)-1 receptors are present in ocular
tissues such as corneal epithelium, keratocytes, and conjunctival cells. Insulin plays a …
tissues such as corneal epithelium, keratocytes, and conjunctival cells. Insulin plays a …
[PDF][PDF] The Utilization of Topical Insulin for Ocular Surface Diseases: A Narrative Review
KA Moin, S Pandiri, GN Manion, AH Brown… - Cureus, 2024 - cureus.com
Various etiologies, including diabetic keratopathy (DK), dry eye disease (DED), and
neurotrophic keratopathy (NK), can disrupt corneal homeostasis, exacerbating corneal …
neurotrophic keratopathy (NK), can disrupt corneal homeostasis, exacerbating corneal …
Evaluating the Safety and Efficacy of Topical Insulin for Ocular Disease: A Systematic Review
LJ de Oliveira Andrade, GC Matos de Oliveira… - medRxiv, 2024 - medrxiv.org
Introduction: Ocular surface disorders are prevalent, impacting millions worldwide and
causing significant morbidity. Conventional treatments often fall short in addressing …
causing significant morbidity. Conventional treatments often fall short in addressing …